Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor α gene

被引:10
作者
Lambertini, E
Piva, R
Khan, MTH
Lampronti, I
Bianchi, N
Borgatti, M
Gambari, R
机构
[1] Univ Ferrara, Dipartmento Biochim & Biol Mol, I-44100 Ferrara, Italy
[2] Univ Ferrara, Interdisciplinary Ctr Study Inflammat, I-44100 Ferrara, Italy
[3] Univ Sci & Technol Chittagong, Fac Pharmaceut Sci, Pharmacol Res Lab, Chittagong, Bangladesh
关键词
Emblica officinalis; Aegle marmelos; Vernonia anthelmintica; Oroxylum indicum; Argemone mexicana; medicinal plants; estrogen receptor alpha; breast cancer; quantitative RT-PCR;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this study we determined the activity of extracts from Bangladeshi medicinal plants (Emblica officinalis, Aegle marmelos, Vernonia anthelmintica, Oroxylum indicum, Argemone mexicana) on human breast tumor cell lines. Extracts from E. officinalis and O. indicum displayed antiproliferative activity on MCF7 and MDA-MB-231 breast cancer cell lines, while extracts from A. mexicana were active on MCF7 cells, exhibiting on the contrary low antiproliferative effects on MDA-MB-231 cells. Extracts from A. marmelos and V. anthelmintica were antiproliferative on both cell lines, but at higher concentrations. The accumulation of estrogen receptor alpha (ERalpha) mRNA, a marker of neoplastic status, was analysed by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). The data obtained demonstrated that only extracts from E. officinalis induce an increase of ERalpha mRNA in MCF7 cells. When MDA-MB-231 cell line was employed, extracts from E. officinalis, V anthelmintica and A. mexicana were found to be inducers of the increase of ERalpha mRNA accumulation. Since activation of ERalpha gene expression could have clinical impact, our results suggest a possible use of extracts from medicinal plants to identify compounds of possible interest in the treatment of breast cancer.
引用
收藏
页码:419 / 423
页数:5
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