Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats

被引：15
|
作者：
He, Jiayi [1 ]
Gong, Jin [1 ]
Ding, Qiang [1 ]
Tan, Qinghai [1 ]
Han, Ping [1 ]
Liu, Jingmei [1 ]
Zhou, Zhenzhen [1 ]
Tu, Wei [1 ]
Xia, Yujia [1 ]
Yan, Wei [1 ]
Tian, Dean [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430074, Peoples R China
来源：
FEBS LETTERS | 2015年 / 589卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Liver fibrosis; Hepatic stellate cell; SATB1; Ras/Raf-1/MEK/ERK/Ets-1; TISSUE GROWTH-FACTOR; PROMOTER ACTIVITY; MULTIPLE GENES; TUMOR-GROWTH; TGF-BETA; EXPRESSION; PROTEIN; BINDING; CANCER; METASTASIS;
D O I：
10.1016/j.febslet.2015.04.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1359 / 1368
页数：10
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