Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats

被引：14
|
作者：
He, Jiayi [1 ]
Gong, Jin [1 ]
Ding, Qiang [1 ]
Tan, Qinghai [1 ]
Han, Ping [1 ]
Liu, Jingmei [1 ]
Zhou, Zhenzhen [1 ]
Tu, Wei [1 ]
Xia, Yujia [1 ]
Yan, Wei [1 ]
Tian, Dean [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430074, Peoples R China
来源：
FEBS LETTERS | 2015年 / 589卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Liver fibrosis; Hepatic stellate cell; SATB1; Ras/Raf-1/MEK/ERK/Ets-1; TISSUE GROWTH-FACTOR; PROMOTER ACTIVITY; MULTIPLE GENES; TUMOR-GROWTH; TGF-BETA; EXPRESSION; PROTEIN; BINDING; CANCER; METASTASIS;
D O I：
10.1016/j.febslet.2015.04.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1359 / 1368
页数：10
相关论文
共 50 条
  • [1] Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx
    Gong, Jin
    Tu, Wei
    Han, Jian
    He, Jiayi
    Liu, Jingmei
    Han, Ping
    Wang, Yunwu
    Li, Mengke
    Liu, Mei
    Liao, Jiazhi
    Tian, Dean
    SCIENTIFIC REPORTS, 2016, 6
  • [2] Effect of ADHI on hepatic stellate cell activation and liver fibrosis in mice
    Zhao, Tianyuan
    Han, Zixinying
    Zhang, Jiamin
    Ding, Ying
    Chen, Jingjing
    Qiao, Hailing
    Gao, Na
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 651 : 98 - 106
  • [3] Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis
    Yang, Ji Hye
    Kim, Kyu Min
    Cho, Sam Seok
    Shin, Sang Mi
    Ka, Sun O.
    Na, Chang-Su
    Park, Byung Hyun
    Jegal, Kyung Hwan
    Kim, Jae Kwang
    Ku, Sae Kwang
    Lee, Hee-Jeong
    Park, Sang-Gon
    Cho, Il Je
    Ki, Sung Hwan
    ANTIOXIDANTS & REDOX SIGNALING, 2019, 31 (03) : 243 - 259
  • [4] Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability
    Xiao-Mei Yang
    Zheng Wu
    Xiaoqi Wang
    Yaoqi Zhou
    Lei Zhu
    Dongxue Li
    Hui-Zhen Nie
    Ya-Hui Wang
    Jun Li
    Xueyun Ma
    BMC Pharmacology and Toxicology, 23
  • [5] Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability
    Yang, Xiao-Mei
    Wu, Zheng
    Wang, Xiaoqi
    Zhou, Yaoqi
    Zhu, Lei
    Li, Dongxue
    Nie, Hui-Zhen
    Wang, Ya-Hui
    Li, Jun
    Ma, Xueyun
    BMC PHARMACOLOGY & TOXICOLOGY, 2022, 23 (01)
  • [6] Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats
    Bian, Er-Bao
    Huang, Cheng
    Wang, Hua
    Chen, Xiao-Xia
    Zhang, Lei
    Lv, Xiong-Wen
    Li, Jun
    TOXICOLOGY LETTERS, 2014, 224 (02) : 175 - 185
  • [7] Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
    Huang, He-Ming
    Zhou, Xiao-Ru
    Liu, Yan-Jun
    Fan, Shi-Jie
    Liao, Li-Ping
    Huang, Jing
    Shi, Cui-Cui
    Yu, Liang
    Pen, Jin-Jin
    Luo, Cheng
    Zhang, Yuan-Yuan
    Li, Guang-Ming
    MOLECULAR MEDICINE REPORTS, 2021, 23 (05)
  • [8] Human antigen R contributes to hepatic stellate cell activation and liver fibrosis
    Woodhoo, Ashwin
    Iruarrizaga-Lejarreta, Marta
    Beraza, Naiara
    Garcia-Rodriguez, Juan L.
    Embade, Nieves
    Fernandez-Ramos, David
    Martinez-Lopez, Nuria
    Gutierrez-De Juan, Virginia
    Arteta, Beatriz
    Caballeria, Juan
    Lu, Shelly C.
    Mato, Jose M.
    Varela-Rey, Marta
    Martinez-Chantar, Maria L.
    HEPATOLOGY, 2012, 56 (05) : 1870 - 1882
  • [9] TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation
    Wang, Jingjie
    Zhang, Yitong
    Ma, Yanyun
    Zhao, Suhan
    Wang, Jiucun
    Chen, Hongtan
    Zhang, Jun
    Liu, Jie
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2024, 39 (07) : 1403 - 1412
  • [10] Lactoferrin as a therapeutic agent for attenuating hepatic stellate cell activation in thioacetamide-induced liver fibrosis
    Pu, Tzu-Yu
    Chuang, Kai-Cheng
    Tung, Min-Che
    Yen, Chih-Ching
    Chen, Yu-Hsuan
    Cidem, Abdulkadir
    Ko, Chu-Hsun
    Chen, Wei
    Chen, Chuan-Mu
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 174
12345