Role of connexin 43 in Sertoli cells of testis

被引:63
|
作者
Sridharan, Santhi [1 ]
Brehm, Ralph [2 ]
Bergmann, Martin [2 ]
Cooke, Paul S. [1 ]
机构
[1] Univ Illinois, Dept Vet Biosci, Urbana, IL 61802 USA
[2] Univ Giessen, Inst Vet Anat Histol & Embryol, Giessen, Germany
来源
TESTICULAR CHROMOSOME STRUCTURE AND GENE EXPRESSION | 2007年 / 1120卷
关键词
spermatogenesis; Sertoli cell proliferation; Sertoli cell differentiation; Cre-loxP; Amh-Cre; floxed Cx43;
D O I
10.1196/annals.1411.004
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Connexin 43 (CX43, also known as GJA1) is the predominant testicular gap-junction protein. In the seminiferous epithelium, gap junctions occur between adjacent Sertoli cells and between Sertoli and germ cells. The specific role of CX43 in Sertoli cell has been difficult to study because of the neonatal lethality of the Cx43 global knockout. Recently two laboratories have independently developed a Sertoli cell conditional Cx43 knockout using Cre-loxP methodology. These have allowed the role of CX43 in Sertoli cells to be determined while circumventing lethal abnormalities in organs such as the heart seen in Cx43 global knockouts. In this review the focus is on the insights into the role of CX43 in Sertoli cells derived from these new model systems. Results indicate that CX43 is essential for cessation of proliferation and normal maturation in Sertoli cells. In addition, CX43 in Sertoli cells is required for spermatogenesis, but not early germ cell proliferation. These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology.
引用
收藏
页码:131 / 143
页数:13
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