Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?

被引：11

作者：

Baradaran, Hediyeh ^{[1
]}

Sarrami, Amir Hossein ^{[1
]}

Gupta, Ajay ^{[2
,3
]}

机构：

[1] Univ Utah, Dept Radiol & Imaging Sci, Salt Lake City, UT 84112 USA

[2] Weill Cornell Med, Dept Radiol, New York, NY USA

[3] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY USA

来源：

FRONTIERS IN NEUROLOGY | 2021年 / 12卷

基金：

美国国家卫生研究院;

关键词：

carotid atherosclerosis; cognitive impairment (CI); dementia; carotid stenosis; carotid plaque (CP); INTIMA-MEDIA THICKNESS; SILENT BRAIN INFARCTION; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; CEREBRAL HEMODYNAMICS; GENE/ENVIRONMENT SUSCEPTIBILITY; ALZHEIMERS-DISEASE; RISK-FACTOR; ATHEROSCLEROSIS; DEMENTIA;

D O I：

10.3389/fneur.2021.741500

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The development of cognitive dysfunction and dementia is a complex, multifactorial process. One of the contributors to various types of cognitive dysfunction is carotid atherosclerosis which can frequently be seen in asymptomatic individuals. There are a number of different manifestations of asymptomatic carotid atherosclerosis including arterial stiffness, carotid intima-media thickening, flow-limiting stenosis, and complex, atherosclerotic plaque. Each of these forms of atherosclerosis may contribute to cerebral parenchymal damage, contributing to cognitive dysfunction. In this review article, we will discuss each of these forms of carotid atherosclerosis, present the potential mechanistic underpinnings behind an association, and then review the scientific evidence supporting potential associations to cognitive dysfunction and dementia.

引用

页数：10

共 94 条

[81] Cognitive Impairment Is Related to Increased Arterial Stiffness and Microvascular Damage in Patients With Never-Treated Essential Hypertension [J].

Triantafyllidi, Helen ;

Arvaniti, Chrysa ;

Lekakis, John ;

Ikonomidis, Ignatios ;

Siafakas, Nikolaos ;

Tzortzis, Stavros ;

Trivilou, Paraskevi ;

Zerva, Loukia ;

Stamboulis, Eleftherios ;

Kremastinos, Dimitrios Th .

AMERICAN JOURNAL OF HYPERTENSION, 2009, 22 (05) :525-530

[82] Carotid intima-media thickness for cardiovascular risk assessment: Systematic review and meta-analysis [J].

van den Oord, Stijn C. H. ;

Sijbrands, Eric J. G. ;

ten Kate, Gerrit L. ;

van Klaveren, David ;

van Domburg, Ron T. ;

van der Steen, Antonius F. W. ;

Schinkel, Arend F. L. .

ATHEROSCLEROSIS, 2013, 228 (01) :1-11

[83] Atherosclerosis and risk for dementia [J].

van Oijen, Marieke ;

de Jong, Frank Jan ;

Witteman, Jacqueline C. M. ;

Hofman, Albert ;

Koudstaal, Peter J. ;

Breteler, Monique M. B. .

ANNALS OF NEUROLOGY, 2007, 61 (05) :403-410

[84] Carotid Stiffness: A Novel Cerebrovascular Disease Risk Factor [J].

van Sloten, Thomas T. ;

Stehouwer, Coen D. A. .

PULSE, 2016, 4 (01) :24-27

[85] Silent brain infarcts and the risk of dementia and cognitive decline [J].

Vermeer, SE ;

Prins, ND ;

den Heijer, T ;

Hofman, A ;

Koudstaal, PJ ;

Breteler, MMB .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (13) :1215-1222

[86] Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study [J].

Wang, Anxin ;

Chen, Guojuan ;

Su, Zhaoping ;

Liu, Xiaoxue ;

Yuan, Xiaodong ;

Jiang, Ruixuan ;

Cao, Yibin ;

Chen, Shuohua ;

Luo, Yanxia ;

Guo, Xiuhua ;

Wu, Shouling ;

Zhao, Xingquan .

JOURNAL OF NEUROLOGY, 2016, 263 (10) :2097-2104

[87] Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J].

Wardlaw, Joanna M. ;

Smith, Eric E. ;

Biessels, Geert J. ;

Cordonnier, Charlotte ;

Fazekas, Franz ;

Frayne, Richard ;

Lindley, Richard I. ;

O'Brien, John T. ;

Barkhof, Frederik ;

Benavente, Oscar R. ;

Black, Sandra E. ;

Brayne, Carol ;

Breteler, Monique ;

Chabriat, Hugues ;

DeCarli, Charles ;

de Leeuw, Frank-Erik ;

Doubal, Fergus ;

Duering, Marco ;

Fox, Nick C. ;

Greenberg, Steven ;

Hachinski, Vladimir ;

Kilimann, Ingo ;

Mok, Vincent ;

van Oostenbrugge, Robert ;

Pantoni, Leonardo ;

Speck, Oliver ;

Stephan, Blossom C. M. ;

Teipel, Stefan ;

Viswanathan, Anand ;

Werring, David ;

Chen, Christopher ;

Smith, Colin ;

van Buchem, Mark ;

Norrving, Bo ;

Gorelick, Philip B. ;

Dichgans, Martin .

LANCET NEUROLOGY, 2013, 12 (08) :822-838

[88] Arterial Stiffness and Cognitive Decline in Well-Functioning Older Adults [J].

Watson, Nora L. ;

Sutton-Tyrrell, Kim ;

Rosano, Caterina ;

Boudreau, Robert M. ;

Hardy, Susan E. ;

Simonsick, Eleanor M. ;

Najjar, Samer S. ;

Launer, Lenore J. ;

Yaffe, Kristine ;

Atkinson, Hal H. ;

Satterfield, Suzanne ;

Newman, Anne B. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2011, 66 (12) :1336-1342

[89] Carotid Revascularization and Its Effect on Cognitive Function: A Prospective Nonrandomized Multicenter Clinical Study [J].

Whooley, Jenna L. ;

David, Brandon C. ;

Woo, Henry H. ;

Hoh, Brian L. ;

Raftery, Kevin B. ;

Siddiqui, Adnan Hussain ;

Westerveld, Michael ;

Amin-Hanjani, Sepideh ;

Ghogawala, Zoher .

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2020, 29 (05)

[90] The worldwide economic impact of dementia 2010 [J].

Wimo, Anders ;

Jonsson, Linus ;

Bond, John ;

Prince, Martin ;

Winblad, Bengt .

ALZHEIMERS & DEMENTIA, 2013, 9 (01) :1-11

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