Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?

被引：11
作者：
Baradaran, Hediyeh [1 ]
Sarrami, Amir Hossein [1 ]
Gupta, Ajay [2 ,3 ]
机构：
[1] Univ Utah, Dept Radiol & Imaging Sci, Salt Lake City, UT 84112 USA
[2] Weill Cornell Med, Dept Radiol, New York, NY USA
[3] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY USA
来源：
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
基金：
美国国家卫生研究院;
关键词：
carotid atherosclerosis; cognitive impairment (CI); dementia; carotid stenosis; carotid plaque (CP); INTIMA-MEDIA THICKNESS; SILENT BRAIN INFARCTION; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; CEREBRAL HEMODYNAMICS; GENE/ENVIRONMENT SUSCEPTIBILITY; ALZHEIMERS-DISEASE; RISK-FACTOR; ATHEROSCLEROSIS; DEMENTIA;
D O I：
10.3389/fneur.2021.741500
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The development of cognitive dysfunction and dementia is a complex, multifactorial process. One of the contributors to various types of cognitive dysfunction is carotid atherosclerosis which can frequently be seen in asymptomatic individuals. There are a number of different manifestations of asymptomatic carotid atherosclerosis including arterial stiffness, carotid intima-media thickening, flow-limiting stenosis, and complex, atherosclerotic plaque. Each of these forms of atherosclerosis may contribute to cerebral parenchymal damage, contributing to cognitive dysfunction. In this review article, we will discuss each of these forms of carotid atherosclerosis, present the potential mechanistic underpinnings behind an association, and then review the scientific evidence supporting potential associations to cognitive dysfunction and dementia.
引用
收藏
页数：10
相关论文
共 94 条
[61]  
Paraskevas KI., IEUR J VASC ENDOVASC, V61, P888, DOI [10.1016/j.ejvs.2021.03.024, DOI 10.1016/J.EJVS.2021.03.024]
[62]   Association Between Carotid Artery Intima-Media Thickness and Combinations of Mild Cognitive Impairment and Pre-Frailty in Older Adults [J].
Park, Jinkee ;
Park, Jong-Hwan ;
Park, Hyuntae .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2019, 16 (16)
[63]   Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia [J].
Pase, Matthew P. ;
Beiser, Alexa ;
Himali, Jayandra J. ;
Tsao, Connie ;
Satizabal, Claudia L. ;
Vasan, Ramachandran S. ;
Seshadri, Sudha ;
Mitchell, Gary F. .
STROKE, 2016, 47 (09) :2256-2261
[64]   Low mini-mental status predicts mortality is asymptomatic carotid arterial stenosis [J].
Pettigrew, LC ;
Thomas, N ;
Howard, VJ ;
Veltkamp, R ;
Toole, JF .
NEUROLOGY, 2000, 55 (01) :30-34
[65]   Longitudinal study of carotid atherosclerosis and white matter hyperintensities:: The EVA-MRI cohort [J].
Pico, F ;
Dufouil, C ;
Lévy, C ;
Besançon, V ;
de Kersaint-Gilly, A ;
Bonithon-Kopp, C ;
Ducimetière, P ;
Tzourio, C ;
Alpérovitch, A .
CEREBROVASCULAR DISEASES, 2002, 14 (02) :109-115
[66]   Arterial stiffness, cognitive decline, and risk of dementia - The Rotterdam study [J].
Poels, Marielle M. F. ;
van Oijen, Marieke ;
Mattace-Raso, Francesco U. S. ;
Hofman, Albert ;
Koudstaal, Peter J. ;
Witteman, Jacqueline C. M. ;
Breteler, Monique M. B. .
STROKE, 2007, 38 (03) :888-892
[67]   Arterial Stiffness: Detection and Consequences in Cognitive Impairment and Dementia of the Elderly [J].
Rabkin, Simon W. .
JOURNAL OF ALZHEIMERS DISEASE, 2012, 32 (03) :541-549
[68]   Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction The Maastricht Study [J].
Rensma, Sytze P. ;
Stehouwer, Coen D. A. ;
Van Boxtel, Martin P. J. ;
Houben, Alfons J. H. M. ;
Berendschot, Tos T. J. M. ;
Jansen, Jaap F. A. ;
Schalkwijk, Casper G. ;
Verhey, Frans R. J. ;
Kroon, Abraham A. ;
Henry, Ronald M. A. ;
Backes, Walter H. ;
Dagnelie, Pieter C. ;
van Dongen, Martin C. J. M. ;
Eussen, Simone J. P. M. ;
Bosma, Hans ;
Kohler, Sebastian ;
Reesink, Koen D. ;
Schram, Miranda T. ;
van Sloten, Thomas T. .
HYPERTENSION, 2020, 75 (06) :1607-1614
[69]   Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study [J].
Romero, Jose R. ;
Preis, Sarah R. ;
Beiser, Alexa ;
DeCarli, Charles ;
D'Agostino, Ralph B. ;
Wolf, Philip A. ;
Vasan, Ramachandran S. ;
Polak, Joseph F. ;
Seshadri, Sudha .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (03)
[70]   Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment The Framingham Study [J].
Romero, Jose R. ;
Beiser, Alexa ;
Seshadri, Sudha ;
Benjamin, Emelia J. ;
Polak, Joseph F. ;
Vasan, Ramachandran S. ;
Au, Rhoda ;
DeCarli, Charles ;
Wolf, Philip A. .
STROKE, 2009, 40 (05) :1590-1596
12345678910