Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?

被引：11
作者：
Baradaran, Hediyeh [1 ]
Sarrami, Amir Hossein [1 ]
Gupta, Ajay [2 ,3 ]
机构：
[1] Univ Utah, Dept Radiol & Imaging Sci, Salt Lake City, UT 84112 USA
[2] Weill Cornell Med, Dept Radiol, New York, NY USA
[3] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY USA
来源：
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
基金：
美国国家卫生研究院;
关键词：
carotid atherosclerosis; cognitive impairment (CI); dementia; carotid stenosis; carotid plaque (CP); INTIMA-MEDIA THICKNESS; SILENT BRAIN INFARCTION; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; CEREBRAL HEMODYNAMICS; GENE/ENVIRONMENT SUSCEPTIBILITY; ALZHEIMERS-DISEASE; RISK-FACTOR; ATHEROSCLEROSIS; DEMENTIA;
D O I：
10.3389/fneur.2021.741500
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The development of cognitive dysfunction and dementia is a complex, multifactorial process. One of the contributors to various types of cognitive dysfunction is carotid atherosclerosis which can frequently be seen in asymptomatic individuals. There are a number of different manifestations of asymptomatic carotid atherosclerosis including arterial stiffness, carotid intima-media thickening, flow-limiting stenosis, and complex, atherosclerotic plaque. Each of these forms of atherosclerosis may contribute to cerebral parenchymal damage, contributing to cognitive dysfunction. In this review article, we will discuss each of these forms of carotid atherosclerosis, present the potential mechanistic underpinnings behind an association, and then review the scientific evidence supporting potential associations to cognitive dysfunction and dementia.
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页数：10
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