Neural Antibody Testing for Autoimmune Encephalitis: A Canadian Single-Centre Experience

被引：11

作者：

Budhram, Adrian ^{[1
,2
]}

Mirian, Ario ^{[1
]}

McFadden, Sean ^{[3
]}

Edmond, Pamela ^{[2
]}

Bhayana, Vipin ^{[2
]}

Yang, Liju ^{[2
]}

机构：

[1] London Hlth Sci Ctr, Dept Clin Neurol Sci, London, ON, Canada

[2] London Hlth Sci Ctr, Dept Pathol & Lab Med, London, ON, Canada

[3] EUROIMMUN Med Diagnost Canada Inc, Mississauga, ON, Canada

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2021年 / 48卷 / 06期

关键词：

Autoimmune disease; Neuroimmunology; Encephalitis; Neural antibody; NMDA RECEPTOR ENCEPHALITIS; DIAGNOSIS; TITERS;

D O I：

10.1017/cjn.2021.23

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neural antibodies have emerged as useful biomarkers in suspected autoimmune encephalitis. We reviewed results of neural antibody testing (anti-N-methyl D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein (LGI1), contactin-associated protein-like 2 (CASPR2), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), gamma-aminobutyric acid type B receptor (GABA(B)R), dipeptidyl-peptidase-like protein-6 (DPPX), IgLON family member 5 (IgLON5) and glutamic acid decarboxylase-65 (GAD65)) using cell-based assays (CBAs) and tissue indirect immunofluorescence (TIIF) at our centre. Our findings suggest increased clinical sensitivity of CBA compared to TIIF. However, this may come at some expense to clinical specificity, as evidenced by possible false-positive results when weak serum positivity by CBA was observed for certain antibodies (i.e. anti-NMDAR, CASPR2). In such cases, correlation with serum TIIF, as well as CSF CBA and TIIF, aids in identifying true-positive results.

引用

页码：859 / 863

页数：5

共 12 条

[1] Anti-contactin-associated protein-2 encephalitis: relevance of antibody titres, presentation and outcome [J].

Bien, C. G. ;

Mirzadjanova, Z. ;

Baumgartner, C. ;

Onugoren, M. D. ;

Grunwald, T. ;

Holtkamp, M. ;

Isenmann, S. ;

Kermer, P. ;

Melzer, N. ;

Naumann, M. ;

Riepe, M. ;

Schaebitz, W. R. ;

von Oertzen, T. J. ;

von Podewils, F. ;

Rauschka, H. ;

May, T. W. .

EUROPEAN JOURNAL OF NEUROLOGY, 2017, 24 (01) :175-186

[2]

Brooks J., 2019, CAN J NEUROL SCI, V47, P1

[3] The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review [J].

Budhram, Adrian ;

Nicolle, Michael W. ;

Yang, Liju .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2018, 45 (05) :577-579

[4] Expanded Phenotypes and Outcomes among 256 LGI1/CASPR2-IgG-Positive Patients [J].

Gadoth, Avi ;

Pittock, Sean J. ;

Dubey, Divyanshu ;

McKeon, Andrew ;

Britton, Jeff W. ;

Schmeling, John E. ;

Smith, Aurelia ;

Kotsenas, Amy L. ;

Watson, Robert E. ;

Lachance, Daniel H. ;

Flanagan, Eoin P. ;

Lennon, Vanda A. ;

Klein, Christopher J. .

ANNALS OF NEUROLOGY, 2017, 82 (01) :79-92

[5] GAD antibodies in neurological disorders - insights and challenges [J].

Graus, Francesc ;

Saiz, Albert ;

Dalmau, Josep .

NATURE REVIEWS NEUROLOGY, 2020, 16 (07) :353-365

[6] A clinical approach to diagnosis of autoimmune encephalitis [J].

Graus, Francesc ;

Titulaer, Maarten J. ;

Balu, Ramani ;

Benseler, Susanne ;

Bien, Christian G. ;

Cellucci, Tania ;

Cortese, Irene ;

Dale, Russell C. ;

Gelfand, Jeffrey M. ;

Geschwind, Michael ;

Glaser, Carol A. ;

Honnorat, Jerome ;

Hoeftberger, Romana ;

Iizuka, Takahiro ;

Irani, Sarosh R. ;

Lancaster, Eric ;

Leypoldt, Frank ;

Pruess, Harald ;

Rae-Grant, Alexander ;

Reindl, Markus ;

Rosenfeld, Myrna R. ;

Rostasy, Kevin ;

Saiz, Albert ;

Venkatesan, Arun ;

Vincent, Angela ;

Wandinger, Klaus-Peter ;

Waters, Patrick ;

Dalmau, Josep .

LANCET NEUROLOGY, 2016, 15 (04) :391-404

[7] Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study [J].

Gresa-Arribas, Nuria ;

Titulaer, Maarten J. ;

Torrents, Abiguei ;

Aguilar, Esther ;

McCracken, Lindsey ;

Leypoldt, Frank ;

Gleichman, Amy J. ;

Alice-Gordon, Rita ;

Rosenfeld, Myrna R. ;

Lynch, David ;

Graus, Francesc ;

Dalmau, Josep .

LANCET NEUROLOGY, 2014, 13 (02) :167-177

[8] Encephalitis and GABAB receptor antibodies Novel findings in a new case series of 20 patients [J].

Hoeftberger, Romana ;

Titulaer, Maarten J. ;

Sabater, Lidia ;

Dome, Balazs ;

Rozsas, Anita ;

Hegedus, Balazs ;

Hoda, Mir Alireza ;

Laszlo, Viktoria ;

Ankersmit, Hendrik Jan ;

Harms, Lutz ;

Boyero, Sabas ;

de Felipe, Alicia ;

Saiz, Albert ;

Dalmau, Josep ;

Graus, Francesc .

NEUROLOGY, 2013, 81 (17) :1500-1506

[9] Improving the antibody-based evaluation of autoimmune encephalitis [J].

McCracken, Lindsey ;

Zhang, Junxian ;

Greene, Maxwell ;

Crivaro, Anne ;

Gonzalez, Joyce ;

Kamoun, Malek ;

Lancaster, Eric .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2017, 4 (06)

[10] Prevalence and treatment of anti-NMDA receptor encephalitis Reply [J].

Titulaer, Maarten J. ;

Kayser, Matthew S. ;

Dalmau, Josep .

LANCET NEUROLOGY, 2013, 12 (05) :425-426

← 1 2 →