Polyketides from Penicillium sp JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum

被引：83

作者：

Lin, Zhenjian ^{[1
]}

Zhu, Tianjiao ^{[1
]}

Fang, Yuchun ^{[1
]}

Gu, Qianqun ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine drugs, Qingdao 266003, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 05期

关键词：

Penicillium; endophytic fungi; Aegiceras corniculatum; Myrsinaceae; polyketides; cytotoxicity;

D O I：

10.1016/j.phytochem.2007.10.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four polyketides, leptosphaerone C (1), penicillenone (2), arugosin 1 (3) and 9-demethyl FR-901235 (4), as well as five known compounds, bacillosporin A (5), bacillosporin C (6), sequoiamonascin D (7), sequoiatone A (8), and sequoiatone B (9) were isolated from the Penicillium sp. JP-1, an endophytic fungus isolated from Aegiceras corniculatum. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectroscopic analyses. Compound 1 showed cytotoxicity against A-549 cells with an IC50 value of 1.45 mu M, while compound 2 showed cytotoxicity against P388 cells with an IC50 value of 1.38 mu M. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1273 / 1278

页数：6

共 11 条

[1] LEPTOSPHAERONE-A AND LEPTOSPHAERONE-B, NEW CYCLOHEXENONES FROM LEPTOSPHAERIA-HERPOTRICHOIDES [J].