Restricted access materials for sample clean-up in the analysis of trace levels of tetracyclines by liquid chromatography Application to food and environmental analysis

被引:49
|
作者
Chico, J. [1 ]
Meca, S. [1 ]
Companyo, R. [1 ]
Prat, M. D. [1 ]
Granados, M. [1 ]
机构
[1] Univ Barcelona, Dept Quim Analit, E-08028 Barcelona, Spain
关键词
tetracyclines; restricted access materials; switching columns; liquid chromatography; milk analysis; water analysis; food analysis; environmental analysis;
D O I
10.1016/j.chroma.2007.12.033
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Restricted access materials (RAM) based on alkyl diol silica (ADS) porous particles were evaluated for the sample clean-up in tetracyclines analysis in milk and water samples by liquid chromatography. RAM with C-4, C-8 and C-18 bonded to the inner pore surfaces were tested, with C-8 providing the best performance. A switching column LC system which combines an ADS C-8 RAM column and an analytical C-18 column connected to a fluorimetric detector was used for tetracyclines analysis. The RAM clean-up removed large peaks that otherwise appeared in the initial time window of the chromatograms, attributed to proteins in milk samples and humic substances in water samples. Thus, quantification of analytes in real samples, especially of the most polar compounds such as oxytetracycline and tetracycline, was clearly improved. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
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