Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress

被引：47

作者：

Behan, Aine T. ^{[1
]}

Van den Hove, Daniel L. A. ^{[2
]}

Mueller, Lynn ^{[2
]}

Jetten, Marlon J. A. ^{[2
]}

Steinbusch, Harry W. M. ^{[2
]}

Cotter, David R. ^{[1
]}

Prickaerts, Jos ^{[2
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Psychiat, RCSI Educ & Res Ctr, Beaumont Hosp, Dublin 9, Ireland

[2] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Neurosci, NL-6200 MD Maastricht, Netherlands

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2011年 / 21卷 / 01期

基金：

爱尔兰科学基金会; 英国惠康基金;

关键词：

Prenatal stress; Mice; Hippocampus; Sexual dimorphism; Psychiatric disorders; DORSOLATERAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; FIBRILLARY ACIDIC PROTEIN; MAJOR DEPRESSIVE DISORDER; CHRONIC MILD STRESS; MATERNAL STRESS; BRAIN-DEVELOPMENT; GLUCOCORTICOID SECRETION; GESTATIONAL STRESS; RESTRAINT STRESS;

D O I：

10.1016/j.euroneuro.2010.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：71 / 79

页数：9

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