Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers

被引：13

作者：

Chianca, Michela ^{[1
]}

Panichella, Giorgia ^{[1
]}

Fabiani, Iacopo ^{[2
]}

Giannoni, Alberto ^{[1
,2
]}

L'Abbate, Serena ^{[1
]}

Aimo, Alberto ^{[1
,2
]}

Del Franco, Annamaria ^{[1
]}

Vergaro, Giuseppe ^{[1
,2
]}

Grigoratos, Chrysanthos ^{[2
]}

Castiglione, Vincenzo ^{[3
]}

Cipolla, Carlo Maria ^{[4
]}

Fedele, Antonella ^{[4
]}

Passino, Claudio ^{[1
,2
]}

Emdin, Michele ^{[1
,2
]}

Cardinale, Daniela Maria ^{[4
]}

机构：

[1] Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy

[2] Fdn Toscana Gabriele Monasterio, Cardiol Div, Pisa, Italy

[3] Pisa Univ Hosp, Cardiol Div, Pisa, Italy

[4] European Inst Oncol, Ist Ricovero & Cura Carattere Sci IRCCS, Cardioncol & Opin Div 2, Cardioncol Unit, Milan, Italy

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

关键词：

cancer; inflammation; cardiovascular disease; cardio-oncology; circulating biomarkers; neuro-hormonal activation; PLACENTAL GROWTH-FACTOR; MACROPHAGE INHIBITORY CYTOKINE-1; DIFFERENTIATION FACTOR 15; MEDICINE PRACTICE GUIDELINES; BRAIN NATRIURETIC PEPTIDE; OF-THE-ART; BREAST-CANCER; CLONAL HEMATOPOIESIS; SERUM-LEVELS; CARCINOEMBRYONIC ANTIGEN;

D O I：

10.3389/fcvm.2022.936654

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer and heart failure are the two leading causes of death in developed countries. These two apparently distinct clinical entities share similar risk factors, symptoms, and pathophysiological mechanisms (inflammation, metabolic disturbances, neuro-hormonal and immune system activation, and endothelial dysfunction). Beyond the well-known cardiotoxic effects of oncological therapies, cancer and heart failure are thought to be tied by a bidirectional relationship, where one disease favors the other and vice versa. In this context, biomarkers represent a simple, reproducible, sensitive and cost-effective method to explore such relationship. In this review, we recapitulate the evidence on cardiovascular and oncological biomarkers in the field of cardioncology, focusing on their role in treatment-naive cancer patients. Cardioncological biomarkers are useful tools in risk stratification, early detection of cardiotoxicity, follow-up, and prognostic assessment. Intriguingly, these biomarkers might contribute to better understand the common pathophysiology of cancer and heart failure, thus allowing the implementation of preventive and treatment strategies in cardioncological patients

引用

页数：15

共 170 条

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