Interleukin 6 receptor (IL-6R) was an independent prognostic factor in cervical cancer

被引：10
作者：
Luan, Shaohong [1 ]
An, Zhijie [1 ]
Bi, Shuna [1 ]
Chen, Long [1 ]
Fan, Jun [1 ]
机构：
[1] Qingdao Municipal Hosp, East Branch, Dept Gynecol, Qingdao 266071, Shandong, Peoples R China
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2018年 / 33卷 / 03期
关键词：
Cervical cancer; Cervical squamous cell carcinoma (CSCC); Cervical adenocarcinoma (CAD); IL-6R; Prognosis; MONOCLONAL-ANTIBODY; PROSTATE-CANCER; TUMOR-GROWTH; EXPRESSION; INVASION; CHEMOTHERAPY; MACROPHAGES; METASTASIS; CARCINOMA; PROMOTES;
D O I：
10.14670/HH-11-920
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
IL-6 has been found to be associated with poor response to chemoradiotherapy and poor overall prognosis of patients with cervical cancer. However, little is known about the clinicopathological significance of IL-6 receptor (IL-6R) expression in the setting of cervical cancer. To investigate the clinicopathological meaning of IL-6R in cervical cancer, expression of IL-6R was detected using immunohistochemistry in cervical cancer tissue microarray composed of 98 cases of cervical cancer and paired normal controls. As further confirmation of expression trend, western-blotting was conducted in another independent 36 pairs of cervical cancer and matched normal controls. Subsequently, the statistical correlation between IL-6R expression and clinicopathological variables was analyzed, including demographic, TNM stage, clinical grading and overall prognosis. IL-6R expression was shown to be remarkably associated with lymph node metastasis, recurrence and overall prognosis. Moreover, only IL-6R expression was observed to be an independent prognostic factor among these variables that could potentially influence the overall prognosis of patients with cervical cancer. In conclusion, IL-6R was shown to be an independent prognostic factor for patients with cervical cancer.
引用
收藏
页码：269 / 276
页数：8
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