Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis

被引：19
|
作者：
Bilak, Joanna M. [1 ,2 ]
Alam, Uazman [3 ,4 ,5 ]
Miller, Christopher A. [6 ]
McCann, Gerry P. [1 ,2 ]
Arnold, Jayanth R. [1 ,2 ]
Kanagala, Prathap [3 ,7 ,8 ]
机构：
[1] Univ Leicester, Dept Cardiovasc Sci, Leicester, England
[2] Glenfield Hosp, Leicester NIHR Biomed Res Ctr, Leicester, England
[3] Liverpool Univ Hosp NHS Fdn Trust, Liverpool, England
[4] Univ Manchester, Inst Human Dev, Div Diabet Endocrinol & Gastroenterol, Manchester, England
[5] Univ Liverpool, Inst Life Course & Med Sci, Dept Cardiovasc & Metab Med, Liverpool, England
[6] Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Med Sci, Div Cardiovasc Sci,Fac Biol Med & Hlth, Manchester, England
[7] Fac Hlth & Life Sci, Liverpool Ctr Cardiovasc Sci, Liverpool, England
[8] Liverpool Univ Hosp NHS Fdn Trust, Dept Cardiol, Longmoor Lane, Liverpool L9 7AL, England
来源：
CARDIAC FAILURE REVIEW | 2022年 / 8卷
基金：
美国国家卫生研究院;
关键词：
Heart failure with preserved ejection fraction; cardiovascular MRI; microvascular dysfunction; fibrosis; diagnosis; prevalence; prognosis; CARDIOVASCULAR MAGNETIC-RESONANCE; MYOCARDIAL BLOOD-FLOW; CORONARY-ARTERY; INSIGHTS; RESERVE; COMORBIDITIES; PERFUSION; OBESITY; ANGINA; ADULTS;
D O I：
10.15420/cfr.2022.12
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of all new heart failure cases in the community. HFpEF is closely associated with chronic lifestyle-related diseases, such as obesity and type 2 diabetes, and clinical outcomes are worse in those with than without comorbidities. HFpEF is pathophysiologically distinct from heart failure with reduced ejection fraction, which may explain, in part, the disparity of treatment options available between the two heart failure phenotypes. The mechanisms underlying HFpEF are complex, with coronary microvascular dysfunction (MVD) being proposed as a potential key driver in its pathophysiology. In this review, the authors highlight the evidence implicating MVD in HFpEF pathophysiology, the diagnostic approaches for identifying MVD (both invasive and non-invasive) and the prevalence and prognostic significance of MVD.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Prevalence and Prognostic Significance of Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
    Arnold, J. Ranjit
    Kanagala, Prathap
    Budgeon, Charley A.
    Jerosch-Herold, Michael
    Gulsin, Gaurav S.
    Singh, Anvesha
    Khan, Jamal N.
    Chan, Daniel C. S.
    Squire, Iain B.
    Ng, Leong L.
    McCann, Gerry P.
    JACC-CARDIOVASCULAR IMAGING, 2022, 15 (06) : 1001 - 1011
  • [2] Coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction
    Dryer, Kathryn
    Gajjar, Mark
    Narang, Nikhil
    Lee, Margaret
    Paul, Jonathan
    Shah, Atman P.
    Nathan, Sandeep
    Butler, Javed
    Davidson, Charles J.
    Fearon, William F.
    Shah, Sanjiv J.
    Blair, Gjohn E. A.
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018, 314 (05): : H1033 - H1042
  • [3] Heart failure with preserved ejection fraction: the role of microvascular dysfunction
    Kopeva, K., V
    Mochula, A., V
    Maltseva, A. N.
    Grakova, E., V
    Shipulin, V. V.
    Gusakova, A. M.
    Zavadovsky, K., V
    BYULLETEN SIBIRSKOY MEDITSINY, 2022, 21 (04): : 88 - 97
  • [4] Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
    D'Amario, Domenico
    Migliaro, Stefano
    Borovac, Josip A.
    Restivo, Attilio
    Vergallo, Rocco
    Galli, Mattia
    Leone, Antonio Maria
    Montone, Rocco A.
    Niccoli, Giampaolo
    Aspromonte, Nadia
    Crea, Filippo
    FRONTIERS IN PHYSIOLOGY, 2019, 10
  • [5] Microvascular dysfunction in patients with heart failure with preserved ejection fraction: A meta-analysis
    Azuma, Mai
    Kato, Shingo
    Fukui, Kazuki
    Horita, Nobuyuki
    Utsunomiya, Daisuke
    MICROCIRCULATION, 2023, 30 (07)
  • [6] Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis
    Ma, Chao
    Luo, Huan
    Fan, Lei
    Liu, Xiaoyan
    Gao, Chengshan
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2020, 53 (07)
  • [7] Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF
    Shah, Sanjiv J.
    Lam, Carolyn S. P.
    Svedlund, Sara
    Saraste, Antti
    Hage, Camilla
    Tan, Ru-San
    Beussink-Nelson, Lauren
    Faxen, Ulrika Ljung
    Fermer, Maria Lagerstrom
    Broberg, Malin A.
    Gan, Li-Ming
    Lund, Lars H.
    EUROPEAN HEART JOURNAL, 2018, 39 (37) : 3439 - 3450
  • [8] The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction
    Weerts, Jerremy
    Mourmans, Sanne G. J.
    Barandiaran Aizpurua, Arantxa
    Schroen, Blanche L. M.
    Knackstedt, Christian
    Eringa, Etto
    Houben, Alfons J. H. M.
    van Empel, Vanessa P. M.
    BIOMOLECULES, 2022, 12 (02)
  • [9] The relationship between coronary microvascular dysfunction, atrial fibrillation and heart failure with preserved ejection fraction
    Ozcan, Cevher
    Allan, Tess
    Besser, Stephanie A.
    de la Pena, Anthony
    Blair, John
    AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE, 2021, 11 (01): : 29 - 38
  • [10] Prevalence of right ventricular dysfunction and prognostic significance in heart failure with preserved ejection fraction
    Kanagala, Prathap
    Arnold, Jayanth R.
    Singh, Anvesha
    Khan, Jamal N.
    Gulsin, Gaurav S.
    Gupta, Pankaj
    Squire, Iain B.
    Ng, Leong L.
    McCann, Gerry P.
    INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2021, 37 (01) : 255 - 266
12345