Iron-Catalyzed Stereoselective Cross-Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents

被引：45

作者：

Rivera, Ana Cristina Parra ^{[1
]}

Still, Raymond ^{[1
]}

Frantz, Doug E. ^{[1
]}

机构：

[1] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 23期

关键词：

acrylates; cross-coupling; enol carbamates; iron catalysis; stereoselective synthesis; TETRASUBSTITUTED OLEFIN SYNTHESIS; ARYLBORONIC ACIDS; ORGANIC-SYNTHESIS; INTERNAL ALKYNES; ALKENES; TOSYLATES; EFFICIENT; ALKENYLATION; TRI; ACTIVATION;

D O I：

10.1002/anie.201601899

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical and highly stereoselective iron-catalyzed cross-coupling reaction of stereodefined enol carbamates and Grignard reagents to yield tri- and tetrasubstituted acrylates is reported. A facile method for the stereoselective generation of these enol carbamates has also been developed.

引用

页码：6689 / 6693

页数：5

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