Facile and Odorless One-Pot Process for the Synthesis of N-Substituted Thioamides via TsCl-Mediated Beckmann Rearrangement of Ketoximes

被引：7

作者：

Liu, Li-Feng ^{[1
]}

An, Na ^{[1
]}

Pi, Hong-Jun ^{[1
]}

Ying, Jun ^{[1
]}

Du, Wenting ^{[1
,2
]}

Deng, Wei-Ping ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Zhejiang Med Coll, Dept Pharm, Hangzhou 310053, Zhejiang, Peoples R China

来源：

SYNLETT | 2011年 / 07期

关键词：

Beckmann rearrangement; thioamides; tosyl chloride; ketoximes; LAWESSONS REAGENT; THIONATION; AMIDES; CONVERSION; CATALYST; LACTAMS; MILD;

D O I：

10.1055/s-0030-1259720

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and odorless one-pot thionation process for the synthesis of N-substituted thioamides using chemically stable and inexpensive thiourea reagent via the Beckmann rearrangement of ketoximes, has been described.

引用

页码：979 / 981

页数：3