In vitro and in vivo highly effective antibacterial activity of carbon dots-modified TiO2 nanorod arrays on titanium

Light-triggered antibacterial therapy has been proven to be a secure and effective way to treat bacterial infection. Nevertheless, the long-term security of the common photosensitizer remains to be seen in the body. In this work, carbon dots (CDs) with good biocompatibility are incorporated into TiO2 nanorods to improve the photocatalytic and photothermal ability of titanium implants under the irradiation of visible light (VL) and near-infrared (NIR) light. The C-TiO2 NR exhibit excellent in vitro and in vivo antimicrobial effect under 660 nm VL and 808 nm NIR light co-irradiation owing to the combined effect of hyperthermia, reactive oxygen species (ROS) and nanorod structure. Besides, C-TiO2 NR can improve the adhesion and diffusion of bone marrow mesenchymal stem cells (BMSCs).