Antifungal rosane diterpenes and other constituents of Hugonia castaneifolia

被引：22

作者：

Baraza, Lilechi D. ^{[1
]}

Joseph, Cosam C. ^{[1
]}

Munissi, Joan J. E. ^{[1
]}

Nkunya, Mayunga H. H. ^{[1
]}

Arnold, Norbert ^{[2
]}

Porzel, Andrea ^{[2
]}

Wessjohann, Ludger ^{[2
]}

机构：

[1] Univ Dar Es Salaam, Dept Chem, Dar Es Salaam, Tanzania

[2] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle, Germany

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 01期

关键词：

Hugonia castaneifolia; linaceae; antifungal; larvicidal; rosane diterpenoids; himachalenoid; 2-hydroxyhenpentacont-2-enal;

D O I：

10.1016/j.phytochem.2007.06.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rosane diterpenoids hugorosenone [3 beta-hydroxyrosa-1(10),15-dien-2-one], 18-hydroxyhugorosenone and 18-hydroxy-3-deoxy-hugorosenone, and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one were isolated as antifungal constituents of H. castaneifolia Engl. root bark, together with the previously reported di-podocarpanoids hugonone A and hugonone B that were weakly active, and 1(10),15-rosadiene-2 beta,3 beta-diol (hugorosenol), 4 alpha-methoxyhimachal-10-en-5 beta-ol (hugonianene B) and 2-hydroxyhenpentacont-2-enal, and the known compounds tetracosyl-(E)-ferrulate and caryophyllene oxide, all of which were inactive. Hugorosenone also exhibited activity against Anopheles gambiae mosquito larvae. Structural determination was achieved based on spectroscopic data. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：200 / 205

页数：6

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