Natural and synthetic polymers as inhibitors of drug efflux pumps

被引：169
作者：
Werle, Martin [1 ]
机构：
[1] Leopold Franzens Univ Innsbruck, Dept Pharmaceut Technol, A-6020 Innsbruck, Austria
来源：
PHARMACEUTICAL RESEARCH | 2008年 / 25卷 / 03期
关键词：
drug delivery; efflux pump inhibitors; P-glycoprotein; P-gp inhibitors; polymeric inhibitors;
D O I：
10.1007/s11095-007-9347-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Inhibition of efflux pumps is an emerging approach in cancer therapy and drug delivery. Since it has been discovered that polymeric pharmaceutical excipients such as Tweens (R) or Pluronics (R) can inhibit efflux pumps, various other polymers have been investigated regarding their potential efflux pump inhibitory activity. Among them are polysaccharides, polyethylene glycols and derivatives, amphiphilic block copolymers, dendrimers and thiolated polymers. In the current review article, natural and synthetic polymers that are capable of inhibiting efflux pumps as well as their application in cancer therapy and drug delivery are discussed.
引用
收藏
页码：500 / 511
页数：12
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