Effect of hypobaric hypoxia on immune function in albino rats

被引：25

作者：

SaiRam, M ^{[1
]}

Sharma, SK ^{[1
]}

Dipti, P ^{[1
]}

Pauline, T ^{[1
]}

Kain, AK ^{[1
]}

Mongia, SS ^{[1
]}

Bansal, A ^{[1
]}

Patra, BD ^{[1
]}

Ilavazhagan, G ^{[1
]}

Devendra, K ^{[1
]}

Selvamurthy, W ^{[1
]}

机构：

[1] Def Inst Physiol & Allied Sci, Delhi 110054, India

来源：

INTERNATIONAL JOURNAL OF BIOMETEOROLOGY | 1998年 / 42卷 / 01期

关键词：

hypoxia; macrophage activation; oxidative stress; immunity;

D O I：

10.1007/s004840050084

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The effect of exposure to hypoxia on macrophage activity, lymphocyte function and oxidative stress was investigated. Hypoxia enhanced peritoneal macrophage activity as revealed by enhanced phagocytosis and free radical production. There was no significant change in antibody titres to sheep red blood cells in either serum or spleen during hypoxia. However, there was a considerable reduction in the delayed-type hypersensitivity response to sheep red blood cells, indicating the impairment of T-cell activity. Hypoxia decreased the blood glutathione (reduced) level and increased plasma malondialdehyde by a factor of about 2. It is therefore speculated that hypoxia imposes an oxidative stress leading to decreased T-cell activity.

引用

页码：55 / 59

页数：5

共 27 条

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