Obesity and Atrial Fibrillation: Epidemiology, Pathogenesis and Effect of Weight Loss

被引：23

作者：

Al-Kaisey, Ahmed M. ^{[1
,2
]}

Kalman, Jonathan M. ^{[1
,2
]}

机构：

[1] Royal Melbourne Hosp, Dept Cardiol, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

来源：

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW | 2021年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

AF; obesity; atrial substrate; epicardial atrial adipose tissue; reverse remodelling; weight loss; risk factor management; EPICARDIAL ADIPOSE-TISSUE; HIGH-FAT DIET; RISK-FACTOR; PERICARDIAL FAT; TRENDS; INFLAMMATION; ASSOCIATION; MYOCARDIUM; MANAGEMENT; REDUCTION;

D O I：

10.15420/aer.2021.36

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The obesity epidemic continues its relentless advance and is paralleled by an increase in the incidence of AF. Several epidemiological studies have highlighted obesity as an independent risk factor for the development of AF. This relationship is likely multifactorial through a number of interacting mechanisms. Weight loss through lifestyle changes or surgery has been associated with reverse remodelling of the atrial substrate and subsequent reduction in AF, making it an essential pillar in the management of AF in obese patients. In this review, the epidemiological data that support the obesity-AF relationship, the current insights into the underlying pathophysiological mechanism, the impact of weight loss on reverse remodelling and AF reduction, and the strategies to achieve weight loss in patients with AF are discussed.

引用

页码：159 / 164

页数：6

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