Alterations of calcium homeostasis in cancer cells

被引：93
|
作者：
Marchi, Saverio [1 ]
Pinton, Paolo [1 ]
机构：
[1] Univ Ferrara, Lab Technol Adv Therapies LTTA, Sect Pathol Oncol & Expt Biol, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy
来源：
CURRENT OPINION IN PHARMACOLOGY | 2016年 / 29卷
关键词：
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HUMAN PROSTATE-CANCER; ENDOPLASMIC-RETICULUM; REGULATES APOPTOSIS; TUMOR-METASTASIS; PLASMA-MEMBRANE; DOWN-REGULATION; CA2+ RELEASE; BH4; DOMAIN; BCL-2;
D O I：
10.1016/j.coph.2016.03.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca2+ levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca2+ homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca2+ signaling.
引用
收藏
页码：1 / 6
页数：6
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