Intracrine androgen biosynthesis and drug resistance

被引：4
作者：
Penning, Trevor M. [1 ]
Asangani, Irfan A. [2 ]
Sprenger, Cynthia [3 ]
Plymate, Stephen [3 ,4 ]
机构：
[1] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, 1315 BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA
[3] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98109 USA
[4] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr GRECC, Seattle, WA 98108 USA
来源：
CANCER DRUG RESISTANCE | 2020年 / 3卷 / 04期
关键词：
Prostate cancer; abiraterone acetate; enzalutamide; aldo-keto reductase 1C3; androgen biosynthesis; ALDO-KETO REDUCTASE; STEROIDOGENIC ENZYME AKR1C3; METASTATIC PROSTATE-CANCER; IN-VITRO METABOLISM; DEPRIVATION THERAPY; ABIRATERONE ACETATE; RECEPTOR GENE; 3-BETA-HYDROXYSTEROID DEHYDROGENASE; SELECTIVE INHIBITORS; ANTITUMOR-ACTIVITY;
D O I：
10.20517/cdr.2020.60
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Castration-resistant prostate cancer is the lethal form of prostate cancer and most commonly remains dependent on androgen receptor (AR) signaling. Current therapies use AR signaling inhibitors (ARSI) exemplified by abiraterone acetate, a P450c17 inhibitor, and enzalutamide, a potent AR antagonist. However, drug resistance to these agents occurs within 12-18 months and they only prolong overall survival by 3-4 months. Multiple mechanisms can contribute to ARSI drug resistance. These mechanisms can include but are not limited to germline mutations in the AR, post-transcriptional alterations in AR structure, and adaptive expression of genes involved in the intracrine biosynthesis and metabolism of androgens within the tumor. This review focuses on intracrine androgen biosynthesis, how this can contribute to ARSI drug resistance, and therapeutic strategies that can be used to surmount these resistance mechanisms.
引用
收藏
页码：912 / 929
页数：18
相关论文
共 131 条
  • [1] Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor
    Adeniji, Adegoke
    Uddin, Md. Jashim
    Zang, Tianzhu
    Tamae, Daniel
    Wangtrakuldee, Phumvadee
    Marnett, Lawrence J.
    Penning, Trevor M.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (16) : 7431 - 7444
  • [2] Development of Potent and Selective Inhibitors of Aldo-Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure-Activity Relationships
    Adeniji, Adegoke O.
    Twenter, Barry M.
    Byrns, Michael C.
    Jin, Yi
    Chen, Mo
    Winkler, Jeffrey D.
    Penning, Trevor M.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) : 2311 - 2323
  • [3] Effect of Dutasteride on the Risk of Prostate Cancer.
    Andriole, Gerald L.
    Bostwick, David G.
    Brawley, Otis W.
    Gomella, Leonard G.
    Marberger, Michael
    Montorsi, Francesco
    Pettaway, Curtis A.
    Tammela, Teuvo L.
    Teloken, Claudio
    Tindall, Donald J.
    Somerville, Matthew C.
    Wilson, Timothy H.
    Fowler, Ivy L.
    Rittmaster, Roger S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (13) : 1192 - 1202
  • [4] Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration- Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide
    Antonarakis, Emmanuel S.
    Lu, Changxue
    Luber, Brandon
    Wang, Hao
    Chen, Yan
    Zhu, Yezi
    Silberstein, John L.
    Taylor, Maritza N.
    Maughan, Benjamin L.
    Denmeade, Samuel R.
    Pienta, Kenneth J.
    Paller, Channing J.
    Carducci, Michael A.
    Eisenberger, Mario A.
    Luo, Jun
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (19) : 2149 - +
  • [5] Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer
    Antonarakis, Emmanuel S.
    Lu, Changxue
    Luber, Brandon
    Wang, Hao
    Chen, Yan
    Nakazawa, Mary
    Nadal, Rosa
    Paller, Channing J.
    Denmeade, Samuel R.
    Carducci, Michael A.
    Eisenberger, Mario A.
    Luo, Jun
    [J]. JAMA ONCOLOGY, 2015, 1 (05) : 582 - 591
  • [6] AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
    Antonarakis, Emmanuel S.
    Lu, Changxue
    Wang, Hao
    Luber, Brandon
    Nakazawa, Mary
    Roeser, Jeffrey C.
    Chen, Yan
    Mohammad, Tabrez A.
    Chen, Yidong
    Fedor, Helen L.
    Lotan, Tamara L.
    Zheng, Qizhi
    De Marzo, Angelo M.
    Isaacs, John T.
    Isaacs, William B.
    Nadal, Rosa
    Paller, Channing J.
    Denmeade, Samuel R.
    Carducci, Michael A.
    Eisenberger, Mario A.
    Luo, Jun
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (11) : 1028 - 1038
  • [7] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
    Arakawa, Hiroshi
    Nakanishi, Takeo
    Yanagihara, Chihiro
    Nishimoto, Tomohiro
    Wakayama, Tomohiko
    Mizokami, Atsushi
    Narniki, Mikio
    Kawai, Keiichi
    Tamai, Ikumi
    [J]. BIOCHEMICAL PHARMACOLOGY, 2012, 84 (08) : 1070 - 1077
  • [8] Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    Attard, Gerhardt
    Reid, Alison H. M.
    Yap, Timothy A.
    Raynaud, Florence
    Dowsett, Mitch
    Settatree, Sarah
    Barrett, Mary
    Parker, Christopher
    Martins, Vanessa
    Folkerd, Elizabeth
    Clark, Jeremy
    Cooper, Colin S.
    Kaye, Stan B.
    Dearnaley, David
    Lee, Gloria
    de Bono, Johann S.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) : 4563 - 4571
  • [9] The backdoor pathway to dihydrotestosterone
    Auchus, RJ
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (09) : 432 - 438
  • [10] 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer
    Barnard, Monique
    Quanson, Jonathan L.
    Mostaghel, Elahe
    Pretorius, Elzette
    Snoep, Jacky L.
    Storbeck, Karl-Heinz
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018, 183 : 192 - 201
12345678910