Current Evidence and Future Directions of Berberine Intervention in Depression

被引：9
作者：
Zhu, Wen-Qian [1 ]
Wu, Hui-Ying [1 ]
Sun, Zhi-Hui [2 ]
Guo, Yi [3 ]
Ge, Tong-Tong [1 ]
Li, Bing-Jin [1 ]
Li, Xin [1 ]
Cui, Ran-Ji [1 ]
机构：
[1] Jilin Univ, Second Hosp, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China
[2] Jilin Univ, Hosp 1, Eastern Div, Dept Pharm, Changchun, Peoples R China
[3] Univ Chinese Med, Affiliated Hosp Changchun, Dept Breast Surg, Changchun, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
berberine; bioamine; depression; natural active ingredients; neuroplasticity; INTRANASAL DELIVERY; BEHAVIORS; ANXIETY; NEUROGENESIS; EXPRESSION; ALKALOIDS; SYMPTOMS; STRESS; RATS;
D O I：
10.3389/fphar.2022.824420
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.
引用
收藏
页数：7
相关论文
共 61 条
[11]   Pharmacological effects of berberine on mood disorders [J].
Fan, Jie ;
Zhang, Kun ;
Jin, Yang ;
Li, Bingjini ;
Gao, Shuohui ;
Zhu, Jiaming ;
Cui, Ranji .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 23 (01) :21-28
[12]   Berberine produces antidepressant-like effects in ovariectomized mice [J].
Fan, Jie ;
Li, Bingjin ;
Ge, Tongtong ;
Zhang, Zhuo ;
Lv, Jiayin ;
Zhao, Jing ;
Wang, Pu ;
Liu, Wei ;
Wang, Xuefeng ;
Mlyniec, Katarzyna ;
Cui, Ranji .
SCIENTIFIC REPORTS, 2017, 7
[13]   Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients [J].
Fan, Ni ;
Luo, Yayan ;
Ou, Yufen ;
He, Hongbo .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2017, 32 (04)
[14]   Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota [J].
Fang, Yuan ;
Zhang, Jindong ;
Zhu, Shiwei ;
He, Meibo ;
Ma, Shurong ;
Jia, Qiong ;
Sun, Qinghua ;
Song, Lijin ;
Wang, Yan ;
Duan, Liping .
PHARMACOLOGICAL RESEARCH, 2021, 165
[15]   Imaging the Role of Inflammation in Mood and Anxiety-related Disorders [J].
Felger, Jennifer C. .
CURRENT NEUROPHARMACOLOGY, 2018, 16 (05) :533-558
[16]   Monoamine neurocircuitry in depression and strategies for new treatments [J].
Hamon, Michel ;
Blier, Pierre .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2013, 45 :54-63
[17]   Antioxidant and antiproliferative properties of water extract from Mahonia bealei (Fort.) Carr. leaves [J].
Hu, Weicheng ;
Yu, Lingling ;
Wang, Myeong-Hyeon .
FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (04) :799-806
[18]   Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress [J].
Huang, Yun-Ling ;
Zeng, Ning-Xi ;
Chen, Jie ;
Niu, Jie ;
Luo, Wu-Long ;
Liu, Ping ;
Yan, Can ;
Wu, Li-Li .
NEURAL REGENERATION RESEARCH, 2020, 15 (06) :1150-1159
[19]   Recent advances and challenges in major depressive disorder [J].
Kim, Yong-Ku .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2021, 111
[20]   Croatian barberry (Berberis croatica Horvat): a new source of berberine-analysis and antimicrobial activity [J].
Kosalec, Ivan ;
Gregurek, Barbara ;
Kremer, Dario ;
Zovko, Marijana ;
Sankovic, Kresimir ;
Karlovic, Ksenija .
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2009, 25 (01) :145-150
1234567