Current Evidence and Future Directions of Berberine Intervention in Depression

被引：9

作者：

Zhu, Wen-Qian ^{[1
]}

Wu, Hui-Ying ^{[1
]}

Sun, Zhi-Hui ^{[2
]}

Guo, Yi ^{[3
]}

Ge, Tong-Tong ^{[1
]}

Li, Bing-Jin ^{[1
]}

Li, Xin ^{[1
]}

Cui, Ran-Ji ^{[1
]}

机构：

[1] Jilin Univ, Second Hosp, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China

[2] Jilin Univ, Hosp 1, Eastern Div, Dept Pharm, Changchun, Peoples R China

[3] Univ Chinese Med, Affiliated Hosp Changchun, Dept Breast Surg, Changchun, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

berberine; bioamine; depression; natural active ingredients; neuroplasticity; INTRANASAL DELIVERY; BEHAVIORS; ANXIETY; NEUROGENESIS; EXPRESSION; ALKALOIDS; SYMPTOMS; STRESS; RATS;

D O I：

10.3389/fphar.2022.824420

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.

引用

页数：7

共 61 条

[1] Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling [J].

Azam, Shofiul ;

Jakaria, Md. ;

Kim, In-Su ;

Kim, Joonsoo ;

Haque, Md. Ezazul ;

Choi, Dong-Kug .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[2] Protective efficacy of Tinospora sinensis against streptozotocin induced pancreatic islet cell injuries of diabetic rats and its correlation to its phytochemical profiles [J].

Banerjee, Anindita ;

Singh, Siddhartha ;

Prasad, Shilpi Kumari ;

Kumar, Sourav ;

Banerjee, Oly ;

Seal, Tapan ;

Mukherjee, Sandip ;

Maji, Bithin Kumar .

JOURNAL OF ETHNOPHARMACOLOGY, 2020, 248

[3] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders [J].

Camuso, Serena ;

La Rosa, Piergiorgio ;

Fiorenza, Maria Teresa ;

Canterini, Sonia .

NEUROBIOLOGY OF DISEASE, 2022, 163

[4] Multifaceted interconnections between macrophage migration inhibitory factor and psychiatric disorders [J].

Chen, Xi ;

Chen, Yifan ;

Qi, Dake ;

Cui, Donghong .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2022, 112

[5] New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal [J].

Chouinard, Guy ;

Chouinard, Virginie-Anne .

PSYCHOTHERAPY AND PSYCHOSOMATICS, 2015, 84 (02) :63-71

[6] Validation of the Oxford Depression Questionnaire: Sensitivity to change, minimal clinically important difference, and response threshold for the assessment of emotional blunting [J].

Christensen, Michael Cronquist ;

Fagiolini, Andrea ;

Florea, Ioana ;

Loft, Henrik ;

Cuomo, Alessandro ;

Goodwin, Guy M. .

JOURNAL OF AFFECTIVE DISORDERS, 2021, 294 :924-931

[7] The Combination of Berberine, Tocotrienols and Coffee Extracts Improves Metabolic Profile and Liver Steatosis by the Modulation of Gut Microbiota and Hepatic miR-122 and miR-34a Expression in Mice [J].

Cossiga, Valentina ;

Lembo, Vincenzo ;

Nigro, Cecilia ;

Mirra, Paola ;

Miele, Claudia ;

D'Argenio, Valeria ;

Leone, Alessia ;

Mazzone, Giovanna ;

Veneruso, Iolanda ;

Guido, Maria ;

Beguinot, Francesco ;

Caporaso, Nicola ;

Morisco, Filomena .

NUTRIENTS, 2021, 13 (04)

[8] Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy [J].

Dare, Regina G. ;

Costa, Ana ;

Nakamura, Celso, V ;

Truiti, Maria C. T. ;

Ximenes, Valdecir F. ;

Lautenschlager, Sueli O. S. ;

Sarmento, Bruno .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 582

[9] Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations [J].

Dhuria, Shyeilla V. ;

Hanson, Leah R. ;

Frey, William H., II .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (04) :1654-1673

[10] Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis [J].

Douglas, James A. ;

Follett, John M. ;

Parmenter, Graeme A. ;

Sansom, Catherine E. ;

Perry, Nigel B. ;

Littler, Ray A. .

FITOTERAPIA, 2010, 81 (07) :925-928

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