Biodegradable Micelles Capable of Mannose-Mediated Targeted Drug Delivery to Cancer Cells

被引：40
作者：
Yin, Lichen [1 ]
Chen, Yongbing [2 ]
Zhang, Zhonghai [3 ]
Yin, Qian [3 ]
Zheng, Nan [3 ]
Cheng, Jianjun [3 ]
机构：
[1] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 2, Dept Cardiothorac Surg, Suzhou 215004, Jiangsu, Peoples R China
[3] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2015年 / 36卷 / 05期
关键词：
micelles; O-carbyxyanhydride; polyesters; ring-opening polymerization; targeted drug delivery; RING-OPENING POLYMERIZATION; BLOCK-COPOLYMER MICELLES; NONVIRAL GENE DELIVERY; INTRACELLULAR TRAFFICKING; CLICK CHEMISTRY; NANOPARTICLES; CORE; POLYMERS; POLYESTERS; SYSTEMS;
D O I：
10.1002/marc.201400650
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.
引用
收藏
页码：483 / 489
页数：7
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