In vitro toxicity evaluation of graphene oxide on A549 cells

被引：1083
作者：
Chang, Yanli [1 ]
Yang, Sheng-Tao [1 ,2 ,3 ]
Liu, Jia-Hui [1 ,2 ,3 ]
Dong, Erya [1 ]
Wang, Yanwen [1 ]
Cao, Aoneng [1 ]
Liu, Yuanfang [1 ,2 ,3 ]
Wang, Haifang [1 ]
机构：
[1] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
[2] Peking Univ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
[3] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
来源：
TOXICOLOGY LETTERS | 2011年 / 200卷 / 03期
关键词：
Graphene oxide; Biocompatibility; Toxicity; Size effect; Cell growth substrate; WALLED CARBON NANOTUBES; PHYSICOCHEMICAL PROPERTIES; CELLULAR UPTAKE; GRAPHITE OXIDE; CYTOTOXICITY; NANOMATERIALS; NANOPARTICLES; TRANSLOCATION; DEPENDENCE; DELIVERY;
D O I：
10.1016/j.toxlet.2010.11.016
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of graphene oxide (GO) by examining the influences of GO on the morphology, viability, mortality and membrane integrity of A549 cells. The results suggest that GO does not enter A549 cell and has no obvious cytotoxicity. But GO can cause a dose-dependent oxidative stress in cell and induce a slight loss of cell viability at high concentration. These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：201 / 210
页数：10
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