Future generations of transistors, sensors, and other devices maybe revolutionized through the use of one-dimensional nanostructures such as nanowires, nanotubes, and nanorods. The unique properties of these nanostructures will set new benchmarks for speed, sensitivity, functionality, and integration. These devices may even be self-powered, harvesting energy directly from their surrounding environment. However, as their critical dimensions continue to decrease and performance demands grow, classical mechanics and associated experimental techniques no longer fully characterize the observed behavior. This perspective examines the evolving role of experimental mechanics in driving the development of these new devices. Emphasis is placed on advances in experimental techniques for comprehensive characterization of size effects and their coupling, as well as assessment of device-level response.