Cyclic 3′-5′ guanosine monophosphate-dependent activity in Leishmania amazonensis

被引：8

作者：

Géigel, LF ^{[1
]}

Leon, LL

机构：

[1] Inst Med Trop Pedro Kouri, Dept Parasitol, Havana, Cuba

[2] Fiocruz MS, Inst Oswaldo Cruz, Dept Imunol, BR-21045900 Rio De Janeiro, RJ, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2003年 / 98卷 / 04期

关键词：

Leishmania amazonensis; cyclic 3 '-5 '-guanosine monophosphate; metacyclogenesis;

D O I：

10.1590/S0074-02762003000400012

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Although there are some data concerning the nitric oxide and the cyclic 3'-5' guanosine monophosphate (cGMP) signaling pathway in tryanosomatids, there is no report about the cGMP-dependent enzymatic activity identification. In this sense, a cGMP dependent activity was detected on soluble fraction from Leishmania amazonensis promastigotes with a high metacyclic level. This information is valuable in order to explore the metabolic pathway of G kinase protein in this parasite.

引用

页码：499 / 500

页数：2

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