Cyclic 3′-5′ guanosine monophosphate-dependent activity in Leishmania amazonensis

被引：8

作者：

Géigel, LF ^{[1
]}

Leon, LL

机构：

[1] Inst Med Trop Pedro Kouri, Dept Parasitol, Havana, Cuba

[2] Fiocruz MS, Inst Oswaldo Cruz, Dept Imunol, BR-21045900 Rio De Janeiro, RJ, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2003年 / 98卷 / 04期

关键词：

Leishmania amazonensis; cyclic 3 '-5 '-guanosine monophosphate; metacyclogenesis;

D O I：

10.1590/S0074-02762003000400012

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Although there are some data concerning the nitric oxide and the cyclic 3'-5' guanosine monophosphate (cGMP) signaling pathway in tryanosomatids, there is no report about the cGMP-dependent enzymatic activity identification. In this sense, a cGMP dependent activity was detected on soluble fraction from Leishmania amazonensis promastigotes with a high metacyclic level. This information is valuable in order to explore the metabolic pathway of G kinase protein in this parasite.

引用

页码：499 / 500

页数：2

共 13 条

[1]

FARBER PM, 1997, MOL BIOCHEM PARASIT, V87, P283

[2] Signal transduction mechanisms in Trypanosoma cruzi [J].

Flawia, MM ;

TellezInon, MT ;

Torres, HN .

PARASITOLOGY TODAY, 1997, 13 (01) :30-33

[3] BIOCHEMISTRY OF THE LEISHMANIA SPECIES [J].

GLEW, RH ;

SAHA, AK ;

DAS, S ;

REMALEY, AT .

MICROBIOLOGICAL REVIEWS, 1988, 52 (04) :412-432

[4] Biochemical and immunological studies of protein kinase C from Trypanosoma cruzi [J].

Gómez, ML ;

Ochatt, CM ;

Kazanietz, MG ;

Torres, HN ;

Téllez-Iñon, MT .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1999, 29 (07) :981-989

[5] PROTEIN KINASE-C IN TRYPANOSOMA-CRUZI EPIMASTIGOTE FORMS - PARTIAL-PURIFICATION AND CHARACTERIZATION [J].

GOMEZ, ML ;

ERIJMAN, L ;

ARAUZO, S ;

TORRES, HN ;

TELLEZINON, MT .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 36 (02) :101-108

[6]

Modabber F., 1987, Tropical disease research: a global partnership. UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases 8th Programme Report: the first ten years, with highlights of the 1985-86 biennium.., P99

[7]

Patel AI, 1997, J PHARMACOL EXP THER, V283, P885

[8] The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei [J].

Shalaby, T ;

Liniger, M ;

Seebeck, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (23) :6197-6206

[9]

ULLOA RM, 1988, BIOCHEM J, V255, P319

[10] Cell biology of Leishmania spp.:: Invading and evading [J].

Vannier-Santos, MA ;

Martiny, A ;

de Souza, W .

CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (04) :297-318

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