5-cinnamoyl- and 5-(ethoxycarbonyl)-6-styryl derivatives of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

被引：15

作者：

Kolosov, Maksim A.

Orlov, Valeriy D.

Vashchenko, Valeriy V.

Shishkina, Svetlana V.

Shishkinb, Oleg V.

机构：

[1] Kharkov Natl Univ, Dept Organ Chem, UA-61077 Kharkov, Ukraine

[2] Natl Acad Sci Ukraine, Kharkov Single Crystals Inst, State Sci Inst, Kharkov, Ukraine

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2007年 / 72卷 / 09期

关键词：

5-acetyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones; pyrimidines; benzaldehydes; chalcones; Claisen-Schmidt reactions; cinnamoyl derivatives;

D O I：

10.1135/cccc20071219

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several 5-cinnamoyl- and 5-(ethoxycarbonyl)-6-styryl derivatives of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones were obtained and their physicochemical properties were investigated. The introduction of alkyl substituent in position 1 of dihydropyrimidine ring was shown to promote the Claisen-Schmidt reaction on acetyl group only; without the alkyl both acetyl and 6-methyl groups participate in the reaction.

引用

页码：1219 / 1228

页数：10

共 40 条

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[7] Bis[(L)prolinato-N,O]Zn-water: A green catalytic system for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones via the Biginelli reaction
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[8] Cyclocondensation reaction of 4-aryl-4-methoxy-1,1,1-trifluoro-3-buten-2-ones with urea Synthesis of novel 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones
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[10] Investigation of 4-amino-5-alkynylpyrimidine-2(1H)-ones as anti-mycobacterial agents
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