Characterization of amino acids using Raman spectroscopy

被引：146

作者：

Jenkins, AL

Larsen, RA

Williams, TB

机构：

[1] Jasco Inc, Applicat Div, Easton, MD 21601 USA

[2] Jacco Int, Hachioji, Tokyo 1930835, Japan

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2005年 / 61卷 / 07期

关键词：

amino acids; peptides; proteins; in vivo; Raman spectroscopy; resonance Raman; micro-probe Raman;

D O I：

10.1016/j.saa.2004.11.055

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A key process in the development of new drugs is elucidation of the interaction between the drug molecule and the target protein. Such knowledge then makes it possible to make systematic structural modifications of the drug molecule to optimize the interaction. Many analytical techniques can be applied to proteins in solution such as circular dichroism, ultraviolet, and fluorescence spectroscopy but these all have limitations. In this paper, we investigate the feasibility of using relatively simple, visible light Raman spectroscopic methods to investigate amino acids and related biopolymers. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：1585 / 1594

页数：10

共 18 条

[1] INTRINSIC AND EXTRINSIC FACTORS IN PROTEIN ANTIGENIC STRUCTURE [J].