Evolution of fluoroquinolone resistance among Escherichia coli urinary tract isolates from a French university hospital:: application of the dynamic regression model

被引:23
作者
Mahamat, A
Lavigne, JP
Fabbro-Peray, P
Kinowski, JM
Daurès, JP
Sotto, A [1 ]
机构
[1] UFR Med Montpellier Nimes, Lab Univ Antibiol, Nimes, France
[2] CHU Nimes, Dept Med Informat, Nimes, France
[3] CHU Nimes, Grp Hosp Univ Caremeau, Nimes, France
[4] Inst Univ Rech Clin, Lab Epidemiol, Montpellier, France
关键词
antibiotic use; dynamic regression model; Escherichia coli; fluoroquinolone resistance; resistance evolution;
D O I
10.1111/j.1469-0691.2005.01098.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Escherichia coli urinary tract isolates were collected in 1997-2003 from Nimes University Hospital in order to investigate long-term trends in antibiotic resistance and to explore the relationship between antibiotic use and the emergence of resistance. Time-series analysis (ARIMA models) and dynamic regression models were used to investigate relationships between antibiotic use and resistance to ofloxacin and ciprofloxacin. Significant increases were seen in the frequency of ofloxacin (8.9 to 16.7%) and ciprofloxacin resistance (6.2 to 10.1%) (p < 0.001). Using multivariate dynamic regression analysis, it was found that an increased use of one defined daily dose (DDD)/1000 patient-days for ofloxacin, ciprofloxacin and norfloxacin induced average increases of 0.81%, 0.65% and 0.53% in E. coli ofloxacin resistance (p < 0.01), with average delays of 4, 4 and 6 months, respectively. An increase of 1 DDD/1000 patient-days of ciprofloxacin, ofloxacin and norfloxacin use induced increases of 0.73%, 0.82% and 0.63% in E. coli ciprofloxacin resistance (p < 0.01), with average delays of 4, 4 and 5 months, respectively. The use of nalidixic acid was not associated significantly with an increase in resistance to fluoroquinolones by multivariate analysis.
引用
收藏
页码:301 / 306
页数:6
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