Innate immune recognition on the intestinal mucosa

被引:37
作者
Lotz, Michael
Menard, Sandrine
Hornef, Mathias
机构
[1] Univ Freiburg, Dept Med Microbiol & Hyg, D-79014 Freiburg, Germany
[2] Karolinska Inst, Swedish Inst Infect Dis Control SMI, S-17177 Stockholm, Sweden
关键词
innate immunity; intestinal mucosa; commensal microflora; host microbe homeostasis; inhibition of TLR4 signaling;
D O I
10.1016/j.ijmm.2007.03.010
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The discovery of transcriptionally activating receptors for microbial structures has provided a deeper understanding of how the immune system manages to sense and localize the presence of harmful microbes and target and shape the adequate host response. However, the recognized microbial structures are common to pathogens and commensal microbes and many body surfaces are constantly exposed to environmental microbial ligands and densely colonized by a bacterial flora such as seen for example in the intestinal tract. Thus, mechanisms must exist that facilitate discrimination between benign and beneficial colonization and potentially harmful invasive infection. Identification of the mechanisms involved and characterization of the underlying molecular processes will add to our understanding of mucosal immune defense and might unravel the etiology and pathogenesis of so far undefined inflammatory conditions. Here, we will discuss factors that might be involved to control inappropriate innate immune activation and ensure the host-microbe homeostasis in the intestinal tract. (c) 2007 Elsevier GmbH. All rights reserved.
引用
收藏
页码:379 / 392
页数:14
相关论文
共 158 条
  • [1] TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
    Abreu, MT
    Arnold, ET
    Thomas, LS
    Gonsky, R
    Zhou, YH
    Hu, B
    Arditi, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) : 20431 - 20437
  • [2] Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    Abreu, MT
    Vora, P
    Faure, E
    Thomas, LS
    Arnold, ET
    Arditi, M
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (03) : 1609 - 1616
  • [3] TLR signaling at the intestinal epithelial interface
    Abreu, MT
    Thomas, LS
    Arnold, ET
    Lukasek, K
    Michelsen, KS
    Arditi, M
    [J]. JOURNAL OF ENDOTOXIN RESEARCH, 2003, 9 (05): : 322 - 330
  • [4] Cutting edge: Cell surface expression and lipopolysaccharide signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages
    Akashi, S
    Shimazu, R
    Ogata, H
    Nagai, Y
    Takeda, K
    Kimoto, M
    Miyake, K
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (07) : 3471 - 3475
  • [5] Toll-like receptor 4-mediated signaling by epithelial surfaces:: necessity or threat?
    Bäckhed, F
    Hornef, M
    [J]. MICROBES AND INFECTION, 2003, 5 (11) : 951 - 959
  • [6] In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    Bambou, JC
    Giraud, A
    Menard, S
    Begue, B
    Rakotobe, S
    Heyman, M
    Taddei, FO
    Cerf-Bensussan, N
    Gaboriau-Routhiau, V
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) : 42984 - 42992
  • [7] Barton GM, 2002, CURR TOP MICROBIOL, V270, P81
  • [8] Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut
    Belenguer, Alvaro
    Duncan, Sylvia H.
    Calder, A. Graham
    Holtrop, Grietje
    Louis, Petra
    Lobley, Gerald E.
    Flint, Harry J.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (05) : 3593 - 3599
  • [9] Transimmortalized mouse intestinal cells (m-ICcl2) that maintain a crypt phenotype
    Bens, M
    Bogdanova, A
    Cluzeaud, F
    Miquerol, L
    Kerneis, S
    Kraehenbuhl, JP
    Kahn, A
    Pringault, E
    Vandewalle, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 270 (06): : C1666 - C1674
  • [10] Paneth cell defensins: key effector molecules of innate immunity
    Bevins, CL
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 : 263 - 266