additive manufacturing;
bone scaffolds;
finite element analysis;
mechanical analysis;
D O I:
10.3390/ma14133546
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
Ideal bone scaffolds for tissue engineering should be highly porous allowing cell attachment, spreading, and differentiation and presenting appropriate biomechanical properties. These antagonistic characteristics usually require extensive experimental work to achieve optimised balanced properties. This paper presents a simulation approach to determine the mechanical behaviour of bone scaffolds allowing the compressive modulus and the deformation mechanisms to be predicted. Polycaprolactone scaffolds with regular square pores and different porosities were considered. Scaffolds were also printed using an extrusion-based additive manufacturing and assessed under compressive loads. Similar designs were used for both simulation and fabrication steps. A good correlation between numerical and experimental results was obtained, highlighting the suitability of the simulation tool for the mechanical design of 3D-printed bone scaffolds.
机构:
Shahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Gharibshahian, Maliheh
Salehi, Majid
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h-index: 0
机构:
Shahroud Univ Med Sci, Sch Med, Dept Tissue Engn, Shahroud, Iran
Shahroud Univ Med Sci, Tissue Engn & Stem Cells Res Ctr, Shahroud, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Salehi, Majid
Beheshtizadeh, Nima
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h-index: 0
机构:
Universal Sci Educ & Res Network USERN, Regenerat Med Grp REMED, Tehran, Iran
Univ Tehran Med Sci, Sch Adv Technol Med, Dept Tissue Engn, Tehran, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Beheshtizadeh, Nima
Kamalabadi-Farahani, Mohammad
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机构:
Shahroud Univ Med Sci, Sch Med, Dept Tissue Engn, Shahroud, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Kamalabadi-Farahani, Mohammad
Atashi, Amir
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h-index: 0
机构:
Shahroud Univ Med Sci, Fac Allied Med Sci, Stem Cell & Tissue Engn Res Ctr, Shahroud, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Atashi, Amir
Nourbakhsh, Mohammad-Sadegh
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h-index: 0
机构:
Semnan Univ, Fac New Sci & Technol, Semnan, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
Nourbakhsh, Mohammad-Sadegh
Alizadeh, Morteza
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h-index: 0
机构:
Shahroud Univ Med Sci, Sch Med, Dept Tissue Engn, Shahroud, IranShahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran
机构:
Tel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
Hebrew Univ Jerusalem, Inst Chem, IL-9190401 Jerusalem, Israel
CSIR, Cent Glass & Ceram Res Inst, Kolkata 700032, IndiaTel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
Das, Mitun
Sharabani-Yosef, Orna
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机构:
Tel Aviv Univ, Dept Biomed Engn, IL-6997801 Tel Aviv, IsraelTel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
Sharabani-Yosef, Orna
Eliaz, Noam
论文数: 0引用数: 0
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机构:
Tel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, IsraelTel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
Eliaz, Noam
Mandler, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Inst Chem, IL-9190401 Jerusalem, IsraelTel Aviv Univ, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel