In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines

被引：44
|
作者：
Jackson, SJ
Houghton, PJ
Retsas, S
Photiou, A
机构：
[1] Kings Coll London, Dept Pharm, Pharmacognosy Res Labs, London SE1 8WA, England
[2] Charing Cross Hosp, Dept Med Oncol, Melanoma Unit, Catherine Griffiths Canc Res Lab, London, England
来源：
PLANTA MEDICA | 2000年 / 66卷 / 08期
关键词：
D O I：
10.1055/s-2000-9778
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Crude dichloromethane extracts of Kigelia pinnata stem bark and fruit showed cytotoxic activity in vitro against cultured melanoma and other cancer cell lines using the Sulphorhodamine B assay, which was used for bioassay-guided fractionation. Thin layer chromatography (TLC) examination of the most active fractions of both stem bark and fruits showed the presence of the same major components which were found to be norviburtinal and beta -sitosterol. Norviburtinal was found to be the most active compound but had little selectivity for melanoma cell lines whilst isopinnatal also showed some cytotoxic: activity. beta -Sitosterol was found to be comparatively inactive. HPLC analysis of the crude extract showed that the amount of norviburtinal present in the plant material did not account for all of the activity of the total extracts.
引用
收藏
页码：758 / 761
页数：4
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