Epigallocatechin gallate: a review

被引：25

作者：

Bartosikova, L. ^{[1
]}

Necas, J. ^{[1
]}

机构：

[1] Palacky Univ, Fac Med & Dent, Olomouc, Czech Republic

来源：

VETERINARNI MEDICINA | 2018年 / 63卷 / 10期

关键词：

epigallocatechin-3-O-gallate; pharmacokinetics; toxicity; biological activity; GREEN TEA POLYPHENOL; PERFORMANCE LIQUID-CHROMATOGRAPHY; MYELOID-LEUKEMIA CELLS; KDA LAMININ RECEPTOR; (-)-EPIGALLOCATECHIN GALLATE; LIPID-PEROXIDATION; EGCG PREPARATIONS; OXIDATIVE STRESS; DOUBLE-BLIND; OSTEOBLASTIC DIFFERENTIATION;

D O I：

10.17221/31/2018-VETMED

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Epigallocatechin gallate is the major component of the polyphenolic fraction of green tea and is responsible for most of the therapeutic benefits of green tea consumption. A number of preclinical in vivo and in vitro experiments as well as clinical trials have shown a wide range of biological and pharmacological properties of polyphenolic compounds such as anti-oxidative, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancer, chemoprotective, neuroprotective and immunomodulatory effects. Epigallocatechin gallate controls high blood pressure, decreases blood cholesterol and body fat and decreases the risk of osteoporotic fractures. Further research should be performed to monitor the pharmacological and clinical effects of green tea and to more clearly elucidate its mechanisms of action and the potential for its use in medicine.

引用

页码：443 / 467

页数：25

共 193 条

[1]

Abu el Wafa Y, 2005, An Med Interna, V22, P298

[2] Regulation of interleukin-1β-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts [J].

Ahmed, Salahuddin ;

Pakozdi, Angela ;

Koch, Alisa E. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (08) :2393-2401

[3] Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals [J].

Anderson, RF ;

Fisher, LJ ;

Hara, Y ;

Harris, T ;

Mak, WB ;

Melton, LD ;

Packer, JE .

CARCINOGENESIS, 2001, 22 (08) :1189-1193

[4] Recent advances in understanding the anti-diabetic actions of dietary flavonoids [J].

Babu, Pon Velayutham Anandh ;

Liu, Dongmin ;

Gilbert, Elizabeth R. .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (11) :1777-1789

[5] Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB [J].

Bai, XC ;

Lu, D ;

Bai, J ;

Zheng, H ;

Ke, ZY ;

Li, XM ;

Luo, SQ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 314 (01) :197-207

[6] Oxidative stress, free radicals and bone remodeling [J].

Banfi, Giuseppe ;

Iorio, Eugenio L. ;

Corsi, Massimiliano M. .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2008, 46 (11) :1550-1555

[7] Association between oxidative stress and bone mineral density [J].

Basu, S ;

Michaëlsson, K ;

Olofsson, H ;

Johansson, S ;

Melhus, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (01) :275-279

[8] A simple isolation method for the major catechins in green tea using high-speed countercurrent chromatography [J].

Baumann, D ;

Adler, S ;

Hamburger, M .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (03) :353-355

[9] Green tea (Camellia sinensis) for the prevention of cancer [J].

Boehm, Katja ;

Borrelli, Francesca ;

Ernst, Edzard ;

Habacher, Gabi ;

Hung, Shao Kang ;

Milazzo, Stefania ;

Horneber, Markus .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (03)

[10] Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis) [J].

Bonkovsky, HL .

ANNALS OF INTERNAL MEDICINE, 2006, 144 (01) :68-71

← 1 2 3 4 5 6 7 8 9 10 →