Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast

被引：70
作者：
Sturley, SL [1 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Physiol & Cellular Biophys, Dept Pediat, Inst Human Nutr, New York, NY 10032 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1529卷 / 1-3期
关键词：
yeast; ergosterol; acyl-coenzyme A:cholesterol acyltransferase; Niemann-Pick C;
D O I：
10.1016/S1388-1981(00)00145-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The model eukaryote Saccharomyces cerevisiae (budding yeast) has provided significant insight into sterol homeostasis. The study of sterol metabolism in a genetically amenable model organism such as yeast is likely to have an even greater impact and relevance to human disease with the advent of the complete human genome sequence. In addition to definition of the sterol biosynthetic pathway, almost to completion, the remarkable conservation of other components of sterol homeostasis are described in this review. (C) 2000 Elsevier Science B.V. All rights reserved.
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收藏
页码：155 / 163
页数：9
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