Determination of HLA-A, -C, -B,-DRB1 allele and haplotype frequency in Japanese population based on family study

被引：142

作者：

Ikeda, N. ^{[1
]}

Kojima, H. ^{[1
]}

Nishikawa, M. ^{[1
]}

Hayashi, K. ^{[1
]}

Futagami, T. ^{[1
]}

Tsujino, T. ^{[1
]}

Kusunoki, Y. ^{[1
]}

Fujii, N. ^{[1
]}

Suegami, S. ^{[1
]}

Miyazaki, Y. ^{[1
]}

Middleton, D. ^{[2
,3
]}

Tanaka, H. ^{[1
]}

Saji, H. ^{[1
]}

机构：

[1] HLA Fdn Lab, Kyoto 6008813, Japan

[2] Royal Liverpool Univ Hosp Trust, Transplant Immunol, Liverpool, Merseyside, England

[3] Univ Liverpool, Liverpool L69 3BX, Merseyside, England

来源：

TISSUE ANTIGENS | 2015年 / 85卷 / 04期

关键词：

allele frequency; family study; haplotype frequency; human leucocyte antigen; Japanese population; WT1 PEPTIDE VACCINE; BONE-MARROW-TRANSPLANTATION; CYTOTOXIC T-LYMPHOCYTES; LEUKOCYTE ANTIGEN-A; CLASS-I; HAN POPULATION; AND-DRB1; ALLELES; SOUTHWEST CHINA; POLYMORPHISMS; IMPACT;

D O I：

10.1111/tan.12536

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study investigates the human leucocyte antigen (HLA) allele and haplotype frequencies in Japanese population. We carried out the frequency analysis in 5824 families living across Japanese archipelago. The studied population has mainly been typed for the purpose of transplant, especially the hematopoietic stem cell transplantation (HSCT). We determined HLA class I (A, B, and C) and HLA class II (DRB1) using Luminex technology. The haplotypes were directly counted by segregation. A total of 44 HLA-A, 29 HLA-C, 75 HLA-B, and 42 HLA-DRB1 alleles were identified. In the HLA haplotypes of A-C-B-DRB1 and C-B, the pattern of linkage disequilibrium peculiar to Japanese population has been confirmed. Moreover, the haplotype frequencies based on family study was compared with the frequencies estimated by maximum likelihood estimation (MLE), and the equivalent results were obtained. The allele and haplotype frequencies obtained in this study could be useful for anthropology, transplantation therapy, and disease association studies.

引用

页码：252 / 259

页数：8

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