Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro

被引：216
作者：
Diem, E
Schwarz, C
Adlkofer, F
Jahn, O
Rüdiger, H
机构：
[1] Med Univ Vienna, Div Occupat Med, A-1090 Vienna, Austria
[2] Verum Fdn, Munich, Germany
来源：
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2005年 / 583卷 / 02期
关键词：
RF-EMF; 1800; MHz; mobile-phone modulations; comet assay;
D O I：
10.1016/j.mrgentox.2005.03.006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cultured human diploid fibroblasts and cultured rat granulosa cells were exposed to intermittent and continuous radiofrequency electromagnetic fields (RF-EMF) used in mobile phones. with different specific absorption rates (SAR) and different mobile-phone modulations. DNA strand breaks were determined by means of the alkaline and neutral comet assay, RF-EMF exposure (1800 MHz SAR 1.2 or 2 W/kg; different modulations; during 4.16 and 24 h; intermittent 5 min on/10 min off or continuous wave) induced DNA single- and double-strand breaks. Effects occurred after 16h exposure in both cell types and after different mobile-phone modulations. The intermittent exposure showed a stronger effect in the comet assay than continuous exposure. Therefore we conclude that the induced DNA damage cannot be based on thermal effects, (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：178 / 183
页数：6
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