Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H2S therapy of cancer

被引：15

作者：

Guo, Xiaoyang ^{[1
,2
]}

Liu, Jia ^{[3
,4
]}

Jiang, Lingdong ^{[5
]}

Gong, Wanjun ^{[5
]}

Wu, Huixia ^{[1
,2
]}

He, Qianjun ^{[3
,4
,5
]}

机构：

[1] Shanghai Normal Univ, Educ Minist, Shanghai Key Lab Rare Earth Funct Mat, Joint Int Res Lab Resource Chem,Minist Educ,Key L, Shanghai 200234, Peoples R China

[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm Key Lab Mol Imaging, Coll Chem & Mat Sci, Shanghai 200234, Peoples R China

[3] Chinese Univ Hong Kong, Cent Lab, Longgang Dist Peoples Hosp Shenzhen, Shenzhen 518172, Guangdong, Peoples R China

[4] Chinese Univ Hong Kong, Affiliated Hosp Provis 3, Shenzhen 518172, Guangdong, Peoples R China

[5] Shenzhen Univ, Sch Biomed Engn, Guangdong Prov Key Lab Biomed Measurements & Ultr, Hlth Sci Ctr,Natl Reg Key Technol Engn Lab Med Ul, Shenzhen 518060, Guangdong, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2021年 / 19卷 / 01期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Pd nanocubes; Hydrogen sulfide; Photothermal therapy; Gas therapy; Nanomedicine; HYDROGEN-SULFIDE; FLUORESCENT-PROBES; NANOPARTICLES; NANOSHEETS; PROGRESS;

D O I：

10.1186/s12951-021-01042-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Photothermal therapy (PTT) frequently cause thermal resistance in tumor cells by inducing the heat shock response, limiting its therapeutic effect. Hydrogen sulfide (H2S) with appropriate concentration can reverse the Warburg effect in cancer cells. The combination of PTT with H2S gas therapy is expected to achieve synergistic tumor treatment. Methods: Here, sulourea (Su) is developed as a thermosensitive/hydrolysable H2S donor to be loaded into Pd nanocubes through in-depth coordination for construction of the Pd-Su nanomedicine for the first time to achieve photo-controlled H2S release, realizing the effective combination of photothermal therapy and H2S gas therapy. Results: The Pd-Su nanomedicine shows a high Su loading capacity (85 mg g(-1)), a high near-infrared (NIR) photothermal conversion efficiency (69.4%), and NIR-controlled H2S release by the photothermal-triggered hydrolysis of Su. The combination of photothermal heating and H2S produces a strong synergetic effect by H2S-induced inhibition of heat shock response, thereby effectively inhibiting tumor growth. Moreover, high intratumoral accumulation of the Pd-Su nanomedicine after intravenous injection also enables photothermal/photoacoustic dual-mode imaging-guided tumor treatment. Conclusions: The proposed NIR-responsive heat/H2S release strategy provides a new approach for effective cancer therapy.

引用

页数：14