Significant Impact of IL-6-174G/C but Inverse Relation with-634 C/G Polymorphism in Patients with Non-Small Cell Lung Cancer in Kashmiri Population

被引：16

作者：

Bhat, Imtiyaz A. ^{[1
]}

Qasim, Lqbal ^{[1
]}

Masoodi, Khalid Z. ^{[2
]}

Paul, Shabeer A. ^{[3
]}

Bhat, Bashir A. ^{[4
]}

Rasool, Roohi ^{[1
]}

Aziz, S. A. ^{[5
]}

Shah, Zafar A. ^{[1
]}

机构：

[1] Sherikashmir Inst Med Sci, Dept Immunol & Mol Med, Srinagar 190011, Kashmir, India

[2] SKLTAST Kashmir, Div Biotechnol, Srinagar, Jammu & Kashmir, India

[3] Sherikashmir Inst Med Sci, Dept Gen Med, Coll Med, Srinagar 190011, Kashmir, India

[4] Sherikashmir Inst Med Sci, Dept Plast Surg, Srinagar 190011, Kashmir, India

[5] Sherikashmir Inst Med Sci, Dept Med Oncol, Srinagar 190011, Kashmir, India

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2015年 / 44卷 / 04期

关键词：

Inflammation; non-small cell lung cancer; polymorphism; restriction fragment length polymorphism (RFLP); INTERLEUKIN-6 LEVELS CORRELATE; C-REACTIVE PROTEIN; SERUM-LEVELS; ENDOGENOUS INTERLEUKIN-6; GENETIC POLYMORPHISMS; PACLITAXEL RESISTANCE; OVARIAN-CANCER; DISEASE STATUS; KAPPA-B; RISK;

D O I：

10.3109/08820139.2015.1004336

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To study the possible role of proinflammatory interleukin 6 -174 G>C (rs 1800795) and -634 C>G (rs 1800796) polymorphism in the pathogenesis of non-small cell lung cancer (NSCLC). A total of 190 NSCLC patients and 200 healthy controls were evaluated for polymorphic analysis of -174 G/C and -634 C/G by PCR-RFLP followed by DNA sequencing. A significant association was observed in the genotypic and allelic distribution of IL-6 -174 G/C in the NSCLC group as compared to control group [OR =2.7 (1.77-4.11), p <0.00011. Smokers with the -174C allele were found to be significantly associated with NSCLC (p = 0.01), while 634C/G SNP showed an inverse relation [OR-0.4, p <0.00011. The present investigation revealed a significant association of the IL6 -174 G/C gene promoter polymorphism with NSCLC, and thus, the IL-6 -174G/C genotype can be considered as one of the biological markers in the etiology of NSCLC.

引用

页码：349 / 360

页数：12

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