Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

被引：20

作者：

Sun, Hongnan ^{[1
]}

Huang, Binbin ^{[1
]}

Lin, Run ^{[1
]}

Yang, Chao ^{[1
]}

Xia, Wujiong ^{[1
]}

机构：

[1] Harbin Inst Technol, Acad Fundamental & Interdisciplinary Sci, State Key Lab Urban Water Resource & Environm, Harbin 150080, Peoples R China

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 11卷

关键词：

ammonium persulfate; aziridine; metal free; morpholine; NOREPINEPHRINE REUPTAKE INHIBITOR; SUBSTITUTED AZIRIDINES; DERIVATIVES; REBOXETINE; ALCOHOLS; ROUTE; SALTS; ACID;

D O I：

10.3762/bjoc.11.59

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an S(N)2-type ring opening followed by cyclization of the resulting haloalkoxy amine.

引用

收藏

页码：524 / 529

页数：6

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