SYNTHESIS OF ROCHE LACTONE VIA THE ENANTIOSELECTIVE ALCOHOLYSIS OF meso-CYCLIC ANHYDRIDE STRATEGY: A PRACTICAL APPROACH EMPLOYING AN EFFICIENT AND REUSABLE ORGANIC MICROGEL AUXILIARIES

被引：5

作者：

Xiong, Fei ^{[1
]}

Xi, Chang-Cheng ^{[1
]}

Ma, Chao ^{[1
]}

Chen, Lu ^{[1
]}

Sun, Ming-Wei ^{[1
]}

Zhang, Xing-Guang ^{[1
]}

Hong, Dan-Feng ^{[1
]}

机构：

[1] Univ Shanghai Sci & Technol, Dept Chem, Shanghai 200093, Peoples R China

来源：

HETEROCYCLES | 2021年 / 102卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DESYMMETRIZATION; (+)-BIOTIN;

D O I：

10.3987/COM-20-14386

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Roche lactone, a key chiral intermediate of the natural water-soluble B series vitamin (+)-biotin, was synthesized from meso-cyclic anhydride in overall yield 78% through three steps, including heterogeneous asymmetric desymmetrization, chemoselective reduction and lactonization.

引用

页码：245 / 253

页数：9

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