Polyfunctional HIV-specific T cells in Post-Treatment Controllers

被引：24

作者：

Samri, Assia ^{[1
,2
]}

Bacchus-Souffan, Charlin ^{[1
,2
]}

Hocqueloux, Laurent ^{[3
]}

Avettand-Fenoel, Veronique ^{[5
,6
]}

Descours, Benjamin ^{[1
,2
]}

Theodorou, Ioannis ^{[1
,2
,7
]}

Larsen, Martin ^{[1
,2
,7
]}

Saez-Cirion, Asier ^{[4
]}

Rouzioux, Christine ^{[5
]}

Autran, Brigitte ^{[1
,2
,7
]}

机构：

[1] INSERM U1135 CIMI, Paris, France

[2] UPMC Univ Paris 06, Sorbonne Univ, CIMI, Paris, France

[3] Reg Hosp Ctr, Infect & Trop Dis Dept, Orleans, France

[4] Inst Pasteur, Unite HIV Inflammat & Persistance, Paris, France

[5] Univ Paris 05, Sorbonne Paris Cite, Fac Med, Paris, France

[6] Hop Necker Enfants Malad, AP HP, Virol Lab, Paris, France

[7] Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France

来源：

AIDS | 2016年 / 30卷 / 15期

关键词：

control; HIV; immune T cells; polyfunctional; spontaneous; IMMUNE-RESPONSES; INFECTION; DISEASE; PREDICT; HLA; REPLICATION; VACCINE; DRIVEN;

D O I：

10.1097/QAD.0000000000001195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4(+) T cells, which might contribute to the posttreatment control of HIV. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：2299 / 2302

页数：4

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