Polyfunctional HIV-specific T cells in Post-Treatment Controllers

被引:24
作者
Samri, Assia [1 ,2 ]
Bacchus-Souffan, Charlin [1 ,2 ]
Hocqueloux, Laurent [3 ]
Avettand-Fenoel, Veronique [5 ,6 ]
Descours, Benjamin [1 ,2 ]
Theodorou, Ioannis [1 ,2 ,7 ]
Larsen, Martin [1 ,2 ,7 ]
Saez-Cirion, Asier [4 ]
Rouzioux, Christine [5 ]
Autran, Brigitte [1 ,2 ,7 ]
机构
[1] INSERM U1135 CIMI, Paris, France
[2] UPMC Univ Paris 06, Sorbonne Univ, CIMI, Paris, France
[3] Reg Hosp Ctr, Infect & Trop Dis Dept, Orleans, France
[4] Inst Pasteur, Unite HIV Inflammat & Persistance, Paris, France
[5] Univ Paris 05, Sorbonne Paris Cite, Fac Med, Paris, France
[6] Hop Necker Enfants Malad, AP HP, Virol Lab, Paris, France
[7] Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France
关键词
control; HIV; immune T cells; polyfunctional; spontaneous; IMMUNE-RESPONSES; INFECTION; DISEASE; PREDICT; HLA; REPLICATION; VACCINE; DRIVEN;
D O I
10.1097/QAD.0000000000001195
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4(+) T cells, which might contribute to the posttreatment control of HIV. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码:2299 / 2302
页数:4
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