[1] Univ Porto, Fac Pharm, Dept Biol Sci, Biochem Lab, P-4050313 Oporto, Portugal
[2] Univ Porto, Inst Mol & Cell Biol IBMC, P-4150180 Oporto, Portugal
[3] Univ Porto, Abel Salazar Biomed Sci Inst, P-4050313 Oporto, Portugal
[4] Univ Porto, UNIFAI, Unit Res & Training Adults & Elderly, P-4050313 Oporto, Portugal
[5] Univ Leon, Inst Biomed IBIOMED, E-24071 Leon, Spain