Dual purpose fibre - SERS pH sensing and bacterial analysis

被引：8

作者：

Fleming, Holly ^{[1
,2
]}

McAughtrie, Sarah ^{[1
,2
]}

Mills, Bethany ^{[2
]}

Tanner, Michael G. ^{[2
,3
]}

Marks, Angus ^{[1
]}

Campbell, Colin J. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3FJ, Midlothian, Scotland

[2] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland

[3] Heriot Watt Univ, Inst Photon & Quantum Sci IPAQS, SUPA, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

ANALYST | 2018年 / 143卷 / 24期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

LOWER RESPIRATORY-TRACT; PAPER; INFECTIONS; SENSORS; LUNG;

D O I：

10.1039/c8an01322e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The exploitation of fibre based Raman probes has been challenged by often complicated fabrication procedures and difficulties in reproducibility. Here, we have demonstrated a simple and cost-effective approach for sensing pH through an optical fibre, by employing a wax patterned filter paper-based substrate for surface enhanced Raman spectroscopy (SERS). Through this method, high reproducibility between fibres was achieved. In addition to sensing pH, it was possible to extract fluid samples containing P. aeruginosa for further analysis. This dual purpose fibre is bronchoscope deployable, and is able to gather information about both the host and pathogen, which may lead to an improved treatment plan in future in vivo applications.

引用

页码：5918 / 5925

页数：8

共 32 条

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