Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents

A facile one-pot synthesis of 2'-amino-2-fluoro-5'-oxo-1'-(4-phenylthiazol-2-yl)1',4',5',6',7',8'- hexahydro-3,4'-biquinoline-3'-carbonitrile derivatives was synthesized in one pot by condensing various 2-fluoroquinoline-3-carbaldehyde 1a-d, enaminones 2a-c and malononitrile or ethylcynoacetate 3a-b in ethanol. All the compounds were characterized by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. All the synthesized compounds were screened for their antibacterial activity against Gram positive bacterial species Streptococcus pneumoniae, Bacillus subtilus and Clostridium tetani, Gram negative bacterial species Escherichia coli, Salmonella typhi and Vibrio cholerae and fungicidal activity against Candida albicans and Aspergillus fumigates. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.