Association of (GT)n Repeats Promoter Polymorphism of Heme Oxygenase-1 Gene with Serum Bilirubin Levels in Healthy Indian Adults

被引：19

作者：

D'Silva, Selma ^{[1
]}

Borse, Vikrant ^{[1
]}

Colah, Roshan B. ^{[1
]}

Ghosh, Kanjaksha ^{[1
]}

Mukherjee, Malay B. ^{[1
]}

机构：

[1] King Edward Mem Hosp, Natl Inst Immunohaematol ICMR, Bombay 400012, Maharashtra, India

来源：

GENETIC TESTING AND MOLECULAR BIOMARKERS | 2011年 / 15卷 / 04期

关键词：

MICROSATELLITE POLYMORPHISM; SUSCEPTIBILITY; EXPRESSION; DISEASE; RISK;

D O I：

10.1089/gtmb.2010.0132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim: The present study was undertaken to investigate a length polymorphism of (GT)n repeats of the heme oxygenase-1 (HMOX-1) gene and its association with serum bilirubin levels in apparently healthy adults. Methods: A total of 211 individuals (normal hematology and liver function test) with bilirubin levels of 1.7 to 22.2 mu M were studied. The (GT)n repeats were analyzed by PCR and subsequent sizing by capillary electrophoresis on the ABI Prism 310 Genetic Analyzer. Results: Polymorphisms of the (GT) n repeats were grouped into three classes: short (S) alleles (< 20 repeats), intermediate (M) alleles (20-28 repeats), and long (L) alleles (>= 29 repeats). The frequencies of the S, M, and L allele groups were 0.10, 0.49, and 0.41, respectively. Carriers of short alleles had significantly higher mean bilirubin levels (13.8 +/- 5.10 mu M) compared with others (9.18 +/- 3.73 mu M, p < 0.001). Conclusion: Short (GT) n alleles of the HMOX-1 gene promoter could be a genetic risk factor for hyperbilirubinemia.

引用

页码：215 / 218

页数：4

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