Melatonin: From Neurobiology to Treatment

被引：32

作者：

Biggio, Giovanni ^{[1
,2
]}

Biggio, Francesca ^{[1
]}

Talani, Giuseppe ^{[2
]}

Mostallino, Maria Cristina ^{[2
]}

Aguglia, Andrea ^{[3
,4
]}

Aguglia, Eugenio ^{[5
]}

Palagini, Laura ^{[6
]}

机构：

[1] Univ Cagliari, Inst Neurosci, Dept Life & Environm Sci, CNR, I-09042 Cagliari, Italy

[2] Inst Neurosci, Natl Res Council CNR, Univ Campus, I-09042 Cagliari, Italy

[3] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Sect Psychiat, I-16128 Genoa, Italy

[4] IRCCS Osped Policlin San Martino, I-16128 Genoa, Italy

[5] Univ Catania, Psychiat Clin Univ Hosp Gaspare Rodol, Dept Clin & Expt Med, I-95124 Catania, Italy

[6] Univ Pisa, Dept Clin & Expt Med, Psychiat Div, I-56126 Pisa, Italy

来源：

BRAIN SCIENCES | 2021年 / 11卷 / 09期

关键词：

melatonin; circadian rhythm; wake/sleep cycle; pregnancy; aging; neuronal plasticity; neuroprotection; SLEEP-DEPRIVATION; BLOOD-PRESSURE; PLASTICITY; STRESS; NEUROGENESIS; RECEPTORS; PREGNANCY; BRAIN; METABOLISM; OLANZAPINE;

D O I：

10.3390/brainsci11091121

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin, the major regulator of the sleep/wake cycle, also plays important physiological and pharmacological roles in the control of neuronal plasticity and neuroprotection. Accordingly, the secretion of this hormone reaches the maximal extent during brain development (childhood-adolescence) while it is greatly reduced during aging, a condition associated to altered sleep pattern and reduced neuronal plasticity. Altogether, these properties of melatonin have allowed us to demonstrate in both experimental models and clinical studies the great chronobiotic efficacy and sleep promoting effects of exogenous melatonin. Thus, the prolonged release formulation of melatonin, present as a drug in the pharmaceutical market, has been recently recommended for the treatment of insomnia in over 55 years old subjects.

引用

页数：12

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